The Role of Genetic Factors in the Development of Idiopathic Scoliosis in the Kazakh Population

Idiopathic Scoliosis Clinical Trial

Official title:

Preventive and Personalized Medicine (2021-2023)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05095129
• Other study ID #: 1192
• Status: Completed
• Start date: March 23, 2022
• Est. completion date: January 20, 2023

Study information

• Verified date: March 2023
• Source: Asfendiyarov Kazakh National Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to identify genetic determinants of susceptibility to idiopathic scoliosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic scoliosis

Recruitment information / eligibility

• Status: Completed
• Enrollment: 400
• Est. completion date: January 20, 2023
• Est. primary completion date: January 20, 2023
• Gender: All
• Age group: 4 Years to 40 Years

Eligibility

Inclusion Criteria:

1. Persons with a doctor-confirmed diagnosis of idiopathic scoliosis;

2. Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs;

3. Hereditary history of scoliosis;

4. Persons who are able and willing to provide written informed consent;

Exclusion Criteria:

1. Patients diagnosed with idiopathic scoliosis under 4 and over 40 years of age;

2. Representatives of the Kazakh ethnic group less than 3 generations;

3. No family history of bilateral idiopathic scoliosis;

4. Patients with an acute period of the inflammatory process (laboratory and clinical signs);

5. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;

6. Pregnant or lactating women;

7. Tuberculosis of any localization in the active phase and in history;

8. Severe and decompensated diseases of the liver and kidneys, cardiovascular system;

9. Severe and decompensated course of endocrine diseases;

10. Autoimmune diseases;

11. Systemic diseases;

12. Oncological diseases;

Related Conditions & MeSH terms

• Idiopathic Scoliosis
• Scoliosis

Intervention

Genetic:
• SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample

Locations

Country	Name	City	State
Kazakhstan	Scientific center of traumatology and orthopedics named after academician Batpenova ND	Almaty

Sponsors (1)

Lead Sponsor	Collaborator
Asfendiyarov Kazakh National Medical University

Country where clinical trial is conducted

Kazakhstan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Genotyping for the SNP associated with liver cirrhosis	Genotype frequency of SNP in the study genes of participants and control participants.	1 year