Idiopathic Parkinson's Disease Clinical Trial
Official title:
The Efficacy of Long-term Whole-body Vibration in the Treatment of Parkinson's Disease
This study will evaluate whether whole-body vibration applied over a 12-week period is effective in treating motor symptoms of Parkinson's disease.
Parkinson's disease (PD) is a progressive neurodegenerative disease resulting in the loss of
dopaminergic neurons projecting from the substantia nigra pars compacta to the striatum.
Whole-body vibration (WBV) is potentially beneficial in treating Parkinson's disease because
it has been shown to elicit effects specific to both the brain and muscular system. Animal
models of PD indicate that whole-body vibration can increase striatal dopamine levels, as
well as the number of dopaminergic neurons in the substantia nigra. These findings were
correlated with increased levels of brain-derived neurotrophic factor.
In addition to the potentially neuroplastic effects, >20 Hz WBV has been shown to improve
muscular performance. Improved muscular performance is believed to be attributed to WBV
induced neuromuscular effects rather than muscle hypertrophy, with the specific mechanism
defined as the tonic vibration reflex.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
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