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Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease — TOP-DYSK  

Idiopathic Parkinson's Disease Clinical Trial

Official title:
Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease

Clinical Trial Summary

The study will involve an eighteen-week, double-blind, placebo-controlled parallel designed comparison between add-on topiramate and add-on placebo to stable treatment with amatadine in the treatment of Parkinson's disease (PD) patients who continue to have dyskinesia on amantadine.

Clinical Trial Description

We conducted a randomized placebo controlled trial of topiramate in PD dyskinetic subjects already on amantadine but with continuing dyskinesia. Topiramate or placebo was introduced in blinded fashion with a gradual titration (topiramate 25-150 mg/d) over 6 weeks and then a maintenance period of 8 weeks. The primary outcome of interest was change from baseline to end of study in total Unified Dyskinesia Rating Scale (UDysRS) score using Intention to Treat analysis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01789047
Study type Interventional
Source Rush University Medical Center
Contact
Status Terminated
Phase Phase 2
Start date March 2013
Completion date July 2016
View Details
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