Zanuburutinib in Relapsed and Refractory iMCD: a Prospective, Single-center, Single-arm Trial — iMCD  

Idiopathic Multicentric Castleman's Disease Clinical Trial

Official title: The Efficacy and Safety of Zanuburutinib in Relapsed and Refractory Idiopathic Multicentric Castleman Disease (iMCD): a Prospective, Single-center, Single-arm Trial

Status Recruiting

Clinical Trial Summary

To explore the effectiveness and safety of Zanuburutinib in relapsed and refractory idiopathic Multicentric Castleman's disease (iMCD) patients.

Clinical Trial Description

This is a single center, open-labeled , single arm, prospective study which includes a safety run-in phase. The primary endpoint is the overall response rate which includes complete response (CR) and partial response (PR) at Week 12 and Week 24. The secondary endpoints include progression-free survival (PFS), overall survival (OS), and adverse events. There are two phases of the study. The first phase is the 'safety run-in phase'which plans to enroll 6 patients who would be observed for safety issues for 12 weeks after study drug administration. If no Grade ≥ 4 (CTCAE) adverse events (AE) occurs during this phase, the study would enter the second phase; if Grade ≥ 4 (CTCAE) AE happens during this phase, the study would be terminated. In the second phase of the study, another 24 patients would be enrolled. All enrolled patients would receive the study drug until progression of disease, intolerability of the drugs or Week 96 and would be followed every 4 weeks in the first 12 weeks, every 12 weeks until Week 48 and every 24 weeks until Week 96. The follow-up phase to assess PFS and OS will last from initiation of study drug to 36 months after enrollment (evaluation would be carried out every 24 weeks after Week 96). The total study duration will be 4 years after the last patient starts study medication. ;

Related Conditions & MeSH terms

• Castleman Disease
• Idiopathic Multicentric Castleman's Disease

• NCT number: NCT04743687
• Study type: Interventional
• Source: Peking Union Medical College Hospital
• Contact: Jian Li, M.D.
• Phone: +86-18610852525
• Email: lijian@pumch.cn
• Status: Recruiting
• Phase: Phase 2
• Start date: January 1, 2021
• Completion date: January 1, 2025