Dialysis Clinical Trial
Official title:
A Comparative Study of Mild Hypothermic Circulatory Arrest Versus Moderate Hypothermic Circulatory Arrest on Aortic Surgery.
By comparing the clinical outcome of patients underwent different hypothermic circulatory arrest (mild hypothermic versus moderate hypothermic) during aortic arch surgery, this study aims to determine the optimal hypothermic circulatory arrest strategy for aortic surgery.
Hypothermic circulatory arrest (HCA) is the cornerstone of aortic surgery. It provides a
bloodless and still operative field. But the side effect of hypothermia also draws people's
concern. With the development of surgical techniques and cardiopulmonary bypass (CPB)
management, the temperature of HCA has been raised from deep hypothermia (14.1-20 degree) to
moderate hypothermia (20.1-28 degree), and it has been a primary choice for many surgeons
around the world. Some of surgeons still tried to push the limit and started using mild
hypothermia (28.1-34 degree), and satisfactory outcome was obtained. However, the optimal
temperature of HCA has not yet been determined.
In this randomized controlled study, 80 informed and consenting patients who are scheduled
for total arch replacement with concomitant proximal aortic reconstruction will be randomized
to mild (28.1-34 degree) or moderate (20.1-28 degree) hypothermia during circulatory arrest.
Clinical outcomes of both groups will be analyzed to determine the optimal temperature for
HCA.
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