Hypoxic Ischemic Encephalopathy Clinical Trial
Official title:
Targeted Temperature Management at 36℃ After In-Hospital Cardiac Arrest Trial(TTM36-IHCA Trial): An Investigator-Initiated, Single-Center, Randomized, Controlled, Assessor-Blinded, Pilot Clinical Trial
The purpose of this study is to determine whether targeted temperature management at
36.0˚C(TTM-36) in patients who remain unconscious after resuscitation from in-hospital
cardiac arrest(IHCA) will reduce death and disability compared with fever control. For this
purpose, the current pilot study will be undertaken to establish the feasibility, safety,
and surrogate outcomes of hypoxic-ischemic brain injury in 60 patients who remain
unconscious after resuscitation from IHCA.
Eligible patients will be randomly assigned in a 2:1 ratio to either TTM-36(n=40) or
conventional treatment group(n=20). Randomization will be performed with stratification
according to initial rhythm (shockable vs. non-shockable).
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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