Hypoxic Ischemic Encephalopathy Clinical Trial
Official title:
Safety and Efficacy Investigation of Patients With Hypoxic Ischemic Encephalopathy by Transplantation of Umbilical Cord Derived Mesenchymal Stem Cells
This study is to evaluate the safety and efficacy of Umbilical Cord Derived Mesenchymal Stem Cells transplantation in hypoxic ischemic encephalopathy.
To date,hypoxic ischemic encephalopathy is refractory, including after carbon monoxide
poisoning, cardiopulmonary resuscitation,hemorrhagic shock and cerebral infarction etc. We
used Mesenchymal Stem Cells via portal vein infusion method to treat hypoxic ischemic
encephalopathy. With different durations of follow-up, we cleared therapeutic effect, the
quality of life and prognostic implications of the cord blood stem cell infusion on hypoxic
ischemic encephalopathy, and evaluated the adverse reactions, through the neurological
function score (NIHSS，Barthel Index), cognitive score (MoCA, MMSE),and the international
uniform Parkinson Rating Scale score (UPDRS). Here, we seek new means for the treatment of
hypoxic ischemic encephalopathy, and provide the basis for clinical for further application
of umbilical cord blood derived Mesenchymal stem cells.
On the basis of conventional therapy, at the same time, selected patients were given by
intravenous infusion of umbilical cord blood stem cells 100-800 million. All patients before
treatment, after treatment for 15days, 90days and 180 days were evaluated respectively the
curative effect. The neurological function score (NIHSS score, Barthel Index) was observed
in patients with the ability to live independently and prognosis; MoCA, MMSE were used in
the evaluation of cognitive function ；UPDRS was used in the evaluation of extrapyramidal
tract function.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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