Hypoxic Ischemic Encephalopathy Clinical Trial
Official title:
MRI Thermal Imaging of Infants Undergoing Cooling for HIE
Verified date | June 2015 |
Source | Vanderbilt University |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Observational |
Hundreds of babies in the world are being treated with brain cooling to prevent brain injury after they lose oxygen at birth. This study will use the newly developed information from the magnet resonance image to determine the actual temperature of the brain. This will enable us to determine if the brain is being uniformly cooled and if techniques that provide cooling need to be changed to improve the injury prevention from cooling.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | June 2018 |
Est. primary completion date | May 2018 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A to 1 Week |
Eligibility |
Inclusion Criteria: - Infants in the NICU who are treated with hypothermia for hypoxic ischemic encephalopathy and who are scheduled to have an MRI for evaluation of the extent of their injury. - Parent and attending physician consent to perform evaluation of MRI thermography. Exclusion Criteria: - Infants too unstable to have MRI scan, defined by being on any cardiac pressor medications or more than 40% oxygen on the ventilator. - Infants too active to obtain MRI without sedation. |
Observational Model: Case-Only, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | Monroe Carell Jr Children's Hospital at Vanderbilt | Nashville | Tennessee |
Lead Sponsor | Collaborator |
---|---|
Vanderbilt University | National Institutes of Health (NIH) |
United States,
Magnetic Resonance Thermal Imaging 5th International Conference on Brain Monitoring and Imaging William F. Walsh1, Jason E. Moore3,4, Subechhya Pradhan3,4, Curtis Wuschensky2, J. Christopher Gatenby3,5, E. Brian Welch3,6 1Division of Neonatology, Vanderbilt University Medical Center, Nashville, TN 2Neuroradiology, Vanderbilt University Medical Center, Nashville, TN 3Institute of Imaging Science, Vanderbilt University, Nashville, TN 4Department of Physics and Astronomy, Vanderbilt University, Nashville, TN 5Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 6Philips Healthcare, Cleveland, OH
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Brain temperature | MRI data will be used to estimate regional brain temperature | Day three of cooling | No |
Secondary | Brain temperature upon rewarming | Estimate of brain temperature when rewarmed | 2 hours after initial MRI | No |
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