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SJOV vs. HFNO for Hypoxia During Procedural Sedation at High Altitudes

Hypoxia Clinical Trial

Official title:
Hypoxemia During Deep Sedation for Gastrointestinal Endoscopy at High Altitudes: High-flow Nasal Oxygen Therapy vs. Supraglottic Jet Oxygenation and Ventilation

Clinical Trial Summary

This study aims to compare the effect of the use of supraglottic jet oxygenation and ventilation (SJOV) with high-flow nasal oxygen therapy (HFNO) on reducing the rate of hypoxia during gastrointestinal endoscopic procedures in deeply sedated patients at high altitudes.

Clinical Trial Description

The participants will be randomly allocated to either SJOV or HFNO in a 1:1 ratio using block randomization with variable block sizes of four or six randomized. In the HFNO group, oxygen supplementation is delivered at 35 liters min-1 with a fraction of inspired oxygen (FiO2) of 100%. In the SJOV group, SJOV is conducted using a Wei nasal jet tube (WNJ, Well Lead Medical Co. Ltd, Guangzhou, China) which is connected to a manual jet ventilator (Well Lead Medical Co. Ltd, Guangzhou, China) via its jet port. The initial settings of SJOV were as follows: driving pressure (DP) 15 psi; respiratory rate (RR) 20 bpm; inspiratory-to-expiratory (I/E) ratio 1:2, and gas supply, 100% oxygen. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05474287
Study type Interventional
Source Peking University People's Hospital
Contact Bailin Jiang
Phone 86-13810986114
Email jiangbailin@bjmu.edu.cn
Status Recruiting
Phase N/A
Start date October 14, 2022
Completion date February 28, 2023
View Details
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