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NCT05256069 Clinical Trial

Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

Hypoxia Clinical Trial

Official title:
Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05256069
Other study ID # 2087402
Secondary ID
Status Recruiting
Phase Early Phase 1
First received
Last updated
Start date April 26, 2023
Est. completion date July 2024

Study information
Verified date May 2024
Source University of Missouri-Columbia
Contact Jacqueline K Limberg, Ph.D.
Phone 5738822455
Email limbergj@missouri.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.

Recruitment information / eligibility
Status Recruiting
Enrollment 35
Est. completion date July 2024
Est. primary completion date July 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 45 Years
Eligibility Inclusion Criteria: - healthy adult men and women; - 18-45 years of age; - BMI 18-30 kg/m2; - non-pregnant/non-breastfeeding; - non-nicotine users; Exclusion Criteria: - Pregnancy, breastfeeding, hormonal contraceptives - Diagnosed sleep apnea - Current smoking/Nicotine use/drug use - Nerve/neurologic disease - Cardiovascular, hepatic, renal, respiratory disease - Blood pressure =140/90 mmHg - Diabetes, Polycystic ovarian syndrome - Communication barriers - Prescription medications - Recent COVID-19 diagnosis with symptoms

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Propranolol Pill
Participants will receive a ß-blockade (propranolol pill, 1 mg/kg dosed based on participant weight).
• Placebo
Participants will receive a placebo in pill form.

Locations
Country Name City State
United States University of Missouri-Columbia Columbia Missouri

Sponsors (2)
Lead Sponsor Collaborator
University of Missouri-Columbia American Heart Association

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Forearm Blood Flow Measured with venous occlusion plethysmography (mL/dL/min) Change from baseline to 5 minutes
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