Hypoxia Clinical Trial
Official title:
Ventilatory Responses to Hypercapnic and Hypoxic Conditions in Hyperventilants
Verified date | December 2021 |
Source | Centre Hospitalier Universitaire Saint Pierre |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
For almost a century, many hypotheses have converged on the idea of altered chemosensitivity in patients suffering from hyperventilation syndrome (HVS). Given the evolution of current technical equipment and the ability to maximise true positives in HVS ( using the revised hyperventilation provocation test), it seems reasonable to investigate central and peripheral chemosensitivities in HVS subjects.
Status | Completed |
Enrollment | 24 |
Est. completion date | October 15, 2021 |
Est. primary completion date | October 15, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 99 Years |
Eligibility | Inclusion Criteria: - A plethysmography within subject's predicted values - A negative metacholine test (no documented allergy) - A hyperventilation provocation test result that is consistent with the Nijmegen questionnaire score, confirming either group classification (HVS+ or HVS-) Exclusion Criteria: - Each of the following known or documented conditions: chronic bronchitis (COPD), emphysema, asthma, cardiac disorder, neurological disorder, gastrointestinal disorder, thyroid disorder or psychological/psychiatric disorder - Suspicious cardio-pulmonary exercise testing (CPET) with cardiac or respiratory limitation - Pregnant women or women in the process of becoming pregnant - Persons with a diving practice (amateur or professional), - High-level athletes, - Active smokers and - persons using morphine, and/or barbiturates, and/or anxiolytics and/or sleeping pills |
Country | Name | City | State |
---|---|---|---|
Belgium | CHU St Pierre | Bruxelles | Brabant |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire Saint Pierre | Université Libre de Bruxelles |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The slope of the ventilatory response to hypercapnia (HCVR) | Ventilation increase (litres/min) per unit increase in PetCO2 (mmHg) using Read's method | baseline - during the test | |
Primary | The slope of the ventilatory response to hypoxia (HOVR) | Ventilation increase (litres/min) per unit decrease in SpO2 (%) using Read's method | baseline - during the test | |
Primary | Ventilatory recruitment threshold (VRT) of the HCVR | From the average baseline ventilation and PetCO2, the VRT id the PetCO2 level at which the ventilatory response is activated | baseline - during the test | |
Primary | Ventilatory recruitment threshold (VRT) of the HOVR | From the average baseline ventilation and SpO2, the VRT is the level of SpO2 at which the ventilatory response is activated | baseline - during the test | |
Secondary | Extrapolated apnoeic threshold of the HCVR | PetCO2 level above which apnoea (zero ventilation) is disrupted, obtained from the extrapolation of the HCVR at the X-axis intersection (when VE=0 l/min) | baseline - during the test | |
Secondary | Dyspnea | Visual analogic scale (VAS) of dyspnea, from 0 (no dyspnea) to 10 (maximal dyspnea) | baseline, end of the test |
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