Hypoxia Clinical Trial - Oxygen Insufflation in Microlaryngoscopies

Status Withdrawn

Clinical Trial Summary

The purpose of this project is to evaluate the efficacy of oxygen insufflation (continuous oxygen flow) to keep oxygen saturation (oxygen levels measured with a pulse oximeter [finger device used in medicine]) at 90% or greater in adult patients undergoing microlaryngoscopy surgery.

Clinical Trial Description

High flow, low pressure oxygen will be supplied in microlaryngoscopy airway surgery. These procedures are usually performed with jet ventilation (UAB) or intermittent apnea (surgery centers). Jet ventilation provides oxygenation with limited ventilation but come with high risks, such as barotrauma, pneumothorax, mucosa drying, and even death in the most severe cases. Intermittent apnea is a nuisance for the surgeon in that surgical time is often interrupted with having to place the endotracheal tube whenever the patient's oxygen saturation levels fall. The solution is oxygen insufflation, which will give extended oxygenation times for the surgeon to operate without the inherent risks associated with jet ventilation. During the procedure, oxygen tubing will be connected to the surgeon's laryngoscope instead of the jet ventilation tubing. Oxygen flows of 15 L/min will be administered through the laryngoscope to the posterior oropharynx. Endotracheal tube will be placed if oxygenation deemed insufficient due to oxygen saturations of <90%. Endotracheal tube will be intermittently placed to check and correct carbon dioxide levels. ;

Study Design

Related Conditions & MeSH terms

Hypoxia

Clinical Trial Details

NCT number	NCT04979533
Study type	Interventional
Source	University of Alabama at Birmingham
Contact
Status	Withdrawn
Phase	N/A
Start date	January 1, 2023
Completion date	May 30, 2023

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04498598` - Structural Modification In Supraglottic Airway Device	N/A
Completed	`NCT05532670` - N600X Low Saturation Accuracy Validation
Enrolling by invitation	`NCT04106401` - Intravascular Volumes in Hypoxia During Antarctic Confinement	N/A
Recruiting	`NCT05883137` - High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Not yet recruiting	`NCT05817448` - Hypoxia-induced Autophagy in the Pathogenesis of MAP
Recruiting	`NCT02661152` - DAHANCA 30: A Randomized Non-inferiority Trial of Hypoxia-profile Guided Hypoxic Modification of Radiotherapy of HNSCC.	Phase 3
Terminated	`NCT02801162` - Evaluation of Accuracy and Precision of a New Arterial Blood Gas Analysis System Blood in Comparison With the Reference Standard	N/A
Not yet recruiting	`NCT02201875` - Intrinsic Periodic Pattern of Breathing	N/A
Completed	`NCT02943863` - Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia	N/A
Completed	`NCT02105298` - Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study)	N/A
Completed	`NCT01922401` - Inverse Ratio Ventilation on Bariatric Operation	N/A
Active, not recruiting	`NCT01681238` - Goal-directed Therapy in High-risk Surgery	N/A
Completed	`NCT01463527` - Using Capnography to Reduce Hypoxia During Pediatric Sedation	N/A
Completed	`NCT01507623` - Value of Capnography During Nurse Administered Propofol Sedation (NAPS)	N/A
Withdrawn	`NCT00638040` - The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression	N/A
Active, not recruiting	`NCT06097754` - Intermittent Exogenous Ketosis (IEK) at High Altitude	N/A
Completed	`NCT04589923` - The VISION-Acute Study
Completed	`NCT05044585` - Evaluation of RDS MultiSense® in Desaturation Analysis in Healthy Volunteers	N/A
Completed	`NCT03659513` - The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy
Completed	`NCT03221387` - Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients	N/A