Hypoxia Clinical Trial
— 3H-ODCOfficial title:
Determination of the Oxygen Dissociation Curve Under the Conditions of an Avalanche Burial With an Air Pocket
Verified date | September 2020 |
Source | Medical University Innsbruck |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In an avalanche burial with an air pocket hypercapnia (and hypoxia) develops within few minutes, hypercapnia increases the rate of cooling and therefore the development of hypothermia. The Triple H Syndrome (Hypoxia, Hypercapnia, Hypothermia) occurs. This specific combination of the three parameters is unique for avalanche burial with an air pocket. Every single parameter has a substantial effect on the hemoglobin-oxygen dissociation curve, but until now no study described the combination of these three parameters. This curve will be measured under these specific conditions in a specifically developed in vitro model, to quantify its shifts and to show if there are combined effects of pCO2 and temperature. The newly developed method will be validated in comparison with an established method. The project will be performed with whole blood, drawn by healthy volunteers, in an experimental setting. The samples will be blinded to the investigator and analyzed in a randomized manner.
Status | Completed |
Enrollment | 30 |
Est. completion date | February 10, 2020 |
Est. primary completion date | November 30, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - 18-40 years - fasted situation - ASA I - Informed Consent Exclusion Criteria: - any drug abuse - any drug intake within the last 10 days - smoking - known hemoglobinopathy - relevant illness within last 14 days - relevant blood loss within last 14 days - pregnancy or breast-feeding - participation in any pharmacological study - exposure to high altitude (> 3000 m) within last 4 weeks |
Country | Name | City | State |
---|---|---|---|
Austria | General and Surgical Critical Care Medicine, Medical University of Innsbruck | Innsbruck |
Lead Sponsor | Collaborator |
---|---|
Medical University Innsbruck | Institute of Mountain Emergency Medicine |
Austria,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | amount of p50 in different levels of hypercapnia and hypothermia | amount of p50 in mmHg (p50 = pO2 when oxygen saturation of hemoglobin is 50%) | day 1 | |
Secondary | amount of p50 shift due to sex | amount of p50 in mmHg (p50 = pO2 when oxygen saturation of hemoglobin is 50%) | day 1 | |
Secondary | amount of inflection point in different levels of hypercapnia and hypothermia | amount of inflection point in mmHg | day 1 |
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