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Effects of Expiratory Pressure on Arterial Oxygenation During Hypoxia — hypex  

Hypoxia Clinical Trial

Official title:
Arterial Oxygenation During Hypoxia : Effects of an Added Expiratory Resistance

Clinical Trial Summary

Altitude tolerance correlates with the level of oxygenation achieved. The aim of the present study is to investigate whether increased expiratory pressure within the thorax is able to improve oxygenation during hypoxic hypoxia.

Clinical Trial Description

Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing.

Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max).

FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored. ;

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01260428
Study type Observational
Source AGIR à Dom
Contact Bernard Wuyam, MD, PhD
Phone 33 (0)4 76 76 93 03
Email BWuyam@chu-grenoble.fr
Status Recruiting
Phase N/A
Start date February 2011
View Details
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