Trauma Clinical Trial
Official title:
Evaluation of Resuscitation Markers in Trauma Patients
Severe trauma patients have an elevated risk of multiple organ failure and death. In order to
increase survival possibilities the initial treatment must be focused into resuscitation from
shock. Traditionally the most common resuscitation markers used are vital signs and urine
output. Unfortunately, many patients might present normal vital signs, but still undergo a
compensated shock with persistent acidosis, hence being able to develop multiple organ
failure and death. Consequently, it is important to define better resuscitation markers for
these patients.
This investigation project consists in an observational prospective study, performed by a
multidisciplinary team, in which different resuscitation markers are evaluated in severe
trauma patients. There will be a specific timing (1st, 8th and 24th hours from arrival)
evaluation of different markers: hemodynamic (vital signs, urine output, etc); analytical
(lactate, base excess, natriuretic atrial peptide); tissue perfusion markers (NIRS);
microcirculation markers (videomicroscopy) and coagulopathy markers (thromboelastometry).
There will be a registry of total volume administration; blood cell transfusions and
vasoactive drug requirements. Each marker will be evaluated in relation to mortality;
multiple organ failure; massive transfusion protocol activation; blood cell transfusion
requirement; surgical control of bleeding requirement and emergent arteriographic
embolization. The objective of this study is to demonstrate which of these markers is better
to predict hemodynamic evolution of severe trauma patients and might become a guide for
resuscitation in the future.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04848376 -
Post-Market Clinical Follow-up Study of A-SPINE's Products
|
||
| Terminated |
NCT03781817 -
Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures
|
Phase 4 | |
| Completed |
NCT04342416 -
Using a Brief Visuospatial Interference Intervention to Reduce Intrusive Memories Among Trauma Exposed Women
|
N/A | |
| Recruiting |
NCT04856449 -
DBT Skills Plus EMDR for BPD and Trauma
|
N/A | |
| Completed |
NCT04356963 -
Adjunct VR Pain Management in Acute Brain Injury
|
N/A | |
| Completed |
NCT05669313 -
The Effects of Hypothermia and Acidosis on Coagulation During Treatment With Rivaroxaban Measured With ROTEM
|
||
| Active, not recruiting |
NCT03622632 -
Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association
|
||
| Recruiting |
NCT04725721 -
Testing FIRST in Youth Outpatient Psychotherapy
|
N/A | |
| Active, not recruiting |
NCT05530642 -
An Augmented Training Program for Preventing Post-Traumatic Stress Injuries Among Diverse Public Safety Personnel
|
N/A | |
| Not yet recruiting |
NCT05649891 -
Checklists Resuscitation Emergency Department
|
N/A | |
| Not yet recruiting |
NCT03696563 -
FreeO2 PreHospital - Automated Oxygen Titration vs Manual Titration According to the BLS-PCS
|
N/A | |
| Withdrawn |
NCT03249129 -
Identification of Autoantibodies and Autoantigens in the Cerebrospinal Fluid of Patients With Spinal Cord Trauma
|
||
| Completed |
NCT02240732 -
Surgical Tourniquets and Cerebral Emboli
|
N/A | |
| Completed |
NCT02227979 -
Effects of PURPLE Cry Intervention
|
N/A | |
| Withdrawn |
NCT01169025 -
Fentanyl vs. Low-Dose Ketamine for the Relief of Moderate to Severe Pain in Aeromedical Patients
|
N/A | |
| Recruiting |
NCT01812941 -
Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients
|
N/A | |
| Completed |
NCT03112304 -
Child STEPS for Youth Mental Health in Maine Sustainability
|
N/A | |
| Completed |
NCT01475344 -
Fibrinogen Concentrate (FGTW) in Trauma Patients, Presumed to Bleed (FI in TIC)
|
Phase 1/Phase 2 | |
| Completed |
NCT01201863 -
Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy
|
Phase 4 | |
| Completed |
NCT01210417 -
Trauma Heart to Arm Time
|
N/A |