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Hypovolemia clinical trials

View clinical trials related to Hypovolemia.

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NCT ID: NCT04139031 Completed - Hypovolemic Clinical Trials

Corrected Flow Time in the Carotid Artery as a Predictor of Fluid Responsiveness in Mechanically Ventilated Patients With Low Tidal Volume in the Intensive Care Unit

Start date: November 5, 2019
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to evaluate predictability of carotid corrected flow time for fluid responsiveness in mechanically ventilated patients with low tidal volume in the intensive care unit.

NCT ID: NCT04056065 Completed - Blood Loss Clinical Trials

PMZ-2010 (Centhaquine) as a Resuscitative Agent for Hypovolemic Shock

Start date: May 29, 2017
Phase: Phase 2
Study type: Interventional

This is a prospective, multi-centric, randomized, double-blind, parallel, controlled phase-II efficacy clinical study of PMZ-2010 therapy in patients with hypovolemic shock. Centhaquine is highly safe and well tolerated. Toxicological studies showed high safety margin in preclinical studies. Its safety and tolerability has been demonstrated in a human phase I study in 25 subjects (CTRI/2014/06/004647; NCT02408731).

NCT ID: NCT04045327 Completed - Hypovolemic Shock Clinical Trials

Efficacy of PMZ-2010 (Centhaquine) a Resuscitative Agent for Hypovolemic Shock

Start date: January 31, 2019
Phase: Phase 3
Study type: Interventional

This is a prospective, multi-centric, randomized, double-blind, parallel, controlled phase-III efficacy clinical study of PMZ-2010 therapy in patients with hypovolemic shock. Centhaquine (previously used names, centhaquin and PMZ-2010; International Non-proprietary Name (INN) recently approved by WHO is centhaquine) has been found to be an effective resuscitative agent in rat, rabbit and swine models of hemorrhagic shock, it decreased blood lactate, increased mean arterial pressure, cardiac output, and decreased mortality. An increase in cardiac output during resuscitation is mainly attributed to an increase in stroke volume. Centhaquine acts on the venous α2B-adrenergic receptors and enhances venous return to the heart, in addition, it produces arterial dilatation by acting on central α2A-adrenergic receptors to reduce sympathetic activity and systemic vascular resistance.

NCT ID: NCT03926910 Completed - Cardiac Surgery Clinical Trials

Ventricular Stimulation as Predictor of Hypovolemia After Cardiac Surgery

TESTI
Start date: July 22, 2019
Phase: N/A
Study type: Interventional

The purpose of the study is to validate a ventricular pacing test as a predictor of preload dependency in post cardiac surgery patients.

NCT ID: NCT03915587 Completed - Hypovolemia Clinical Trials

Bedside Resources to Gauge Intravascular Volume Status

Start date: April 8, 2019
Phase: N/A
Study type: Interventional

The goal if this study is to employ the CardioQ-Esophageal Aortic Doppler probe to define fluid responders from non-responders among infants undergoing cranial vault reconstruction for craniosynostosis. After defining these two groups in this single arm prospective trial, the investigators will compare the predictive utility of non-invasive devices such as the CipherOx-Compensatory Reserve Index (CipherOx-CRI) and Inferior Vena Cava Collapsibility Index (IVC CI) to currently employed indices (heart rate, systolic blood pressure, urine output and pulse pressure variability) to gauge the need for additional fluid and ongoing resuscitation. If the CipherOx-CRI or IVC CI proved to be as predictive or better at predicting fluid responders, the investigators hope to replace invasive arterial lines with non-invasive tools to guide resuscitation.

NCT ID: NCT03894800 Completed - Trauma Clinical Trials

Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl

Start date: April 23, 2019
Phase: Phase 4
Study type: Interventional

The aim of this study is to determinate the equipotent doses of inhaled metoxyflurane vs. intravenous fentanyl.

NCT ID: NCT03788096 Recruiting - Sepsis Clinical Trials

Peer Support for Post Intensive Care Syndrome Self-Management

PS-PICS
Start date: April 20, 2020
Phase: N/A
Study type: Interventional

A prospective, 2-arm, single-blind, randomized controlled clinical feasibility trial design is planned. Forty CCI survivors will be randomized (1:1) to either the PS-PICS (peer support) intervention or usual care (control) group.

NCT ID: NCT03764631 Completed - Clinical trials for Diabetes Mellitus, Type 2

Post-authorization Safety Study in Type 2 Diabetic Patients in Saudi Arabia Treated With Empagliflozin to Assess the Incidence of Ketoacidosis, Severe Complications of Urinary Tract Infection, Volume Depletion, and Dehydration

Start date: September 26, 2018
Phase:
Study type: Observational

The objectives of this study are to assess the risk of ketoacidosis, severe urinary tract infections, volume depletion, and dehydration associated in patients with T2DM initiating Empagliflozin compared to patient initiating a dipeptidyl peptidase-4 (DPP-4) inhibitors over a 12-month period of follow-up, including the month of Ramadan

NCT ID: NCT03736421 Suspended - Septic Shock Clinical Trials

Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients

PIVA
Start date: November 10, 2018
Phase:
Study type: Observational

The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the relationship between PIVA and intravenous volume administration during resuscitation of infected patients with presumed hypovolemia; and, the relationship between PIVA and volume decreases during diuresis in acute heart failure patients with hypervolemia.

NCT ID: NCT03644654 Completed - Hypovolemia Clinical Trials

Perioperative Fluid Therapy Optimization in Spinal Surgery

Start date: August 21, 2018
Phase: N/A
Study type: Interventional

The decision to give fluids perioperatively could be based on methods used to identify preload responsiveness, either invasive or noninvasive estimates of stroke volume variation during mechanical ventilation. This study compares fluid management using continuous noninvasive cardiac output measurement with standard perioperative fluid management.