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A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia

Hypotension Drug-Induced Clinical Trial

Official title:
Effects of Vasopressor on Cerebral Oxygenation During General Anesthesia in Abdominal Surgery

Clinical Trial Summary

The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.

Clinical Trial Description

This study was a single-center, randomized, double-blinded, controlled trial. First, the effects of E, P, or N on cerebral oxygen saturation(rScO2) under general anesthesia in abdominal surgery were studied. Patients with abdominal surgery were evaluated using near-infrared spectroscopy. Continual changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO) and systemic vascular resistance (SVR) will be measured with LiDCO rapidV3 monitoring system. To investigate the individualized therapeutic options & specific mechanisms of the three vasopressors on rScO2 and CO. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06334549
Study type Interventional
Source Dalian Municipal Central Hospital
Contact Liping Han, MD, MSc
Phone 86-411-84412001
Email han651310@163.com
Status Recruiting
Phase Phase 4
Start date March 5, 2024
Completion date December 5, 2024
View Details
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