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Hypospadias clinical trials

View clinical trials related to Hypospadias.

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NCT ID: NCT02512887 Recruiting - Hypospadias Clinical Trials

Caudal vs Local Anesthesia in Hypospadias

CLASH
Start date: July 2016
Phase: N/A
Study type: Interventional

Hypospadias is one of the most common congenital malformations of the genitalia in boys, and is typically managed by surgical intervention. During pediatric urological surgery, caudal anesthesia is one of the most common regional anesthetic techniques used. Also known as caudal block, it has been shown to be a safe and effective anesthetic technique in children with a low incidence of anesthesia-related complications.While the reported incidence of complications directly associated with caudal block is low, there is scarce and inconclusive evidence on the impact of caudal anesthesia on the incidence of surgical complications. As a result, the objective of this superiority, randomized controlled trial is to assess whether the use of caudal anesthesia, when compared to dorsal penile block, is associated with a higher rate of urethrocutaneous fistulas and glans dehiscence post hypospadias repair.

NCT ID: NCT02497963 Not yet recruiting - Hypospadias Clinical Trials

Foreskin Graft Tubularized Incised Plate Urethroplasty vs Tubularized Incised Plate for Primary Hypospadias (FGTIP-TIP)

FGTIP-TIP
Start date: August 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the efficacy and safety of tubularized incised plate urethroplasty versus foreskin graft tubularized incised plate urethroplasty in primary hypospadias. This study only included patients with width of urethral plate ≤ 7 mm, width of glans ≤ 14 mm, and urethral plate depth shallow o moderate.

NCT ID: NCT02495090 Completed - Hypospadias Clinical Trials

Hypospadias and Exome: Identification of New Genes for Familial Hypospadias

Start date: November 13, 2014
Phase: N/A
Study type: Interventional

Hypospadias is the second most common malformation of the male genitalia and consists in a congenital hypoplasia of its ventral face. Hypospadias results from abnormal development of the penis that leaves the urethral meatus proximal to its normal glanular position. Meatus position may be located anywhere along the penile shaft, but more severe forms of hypospadias may have a urethral meatus located at the scrotum or perineum. Glandular and penile anterior represents approximately 70% of all the diagnosed cases. The frequency of family reached depend on the severity of hypospadias. The number of children which have hypospadias mutation discovered by classical technique is low. Families are often the cause of the discovery of new genes involved in sexual differentiation because they allow comparison of genomes of related persons, and detect more easily mutations.

NCT ID: NCT02390388 Completed - Pain Clinical Trials

Pudendal Block Versus Caudal Block for Hypospadias

Start date: November 2014
Phase: Phase 4
Study type: Interventional

The aim of this prospective randomized study is to assess the analgesic efficacy and duration of Pudendal block compared with Caudal block for pediatric patients undergoing hypospadias surgery concerning intraoperative analgesic and also postoperative total analgesic consumption within 24 hours.

NCT ID: NCT02268019 Recruiting - Hypospadias Repair Clinical Trials

Hemostasis During Hypospadias Surgery

Start date: January 2013
Phase: N/A
Study type: Interventional

A comparison between the two hemostatic methods of hypospadias repairing operation, in terms of early and mid-term (up to 6 months) failure rate (wound dehiscence and urethral stricture needing reoperation) between the two groups: Group A) diluted Epinephrine injection, Group B) tourniquet application in children

NCT ID: NCT02164682 Completed - Hypospadias Clinical Trials

The Effect of Caudal Block on the Postoperative Complications in Pediatric Patients After Hypospadias Repair

Start date: June 2014
Phase: N/A
Study type: Observational

Hypospadias refers to a disease represented by a congenital defect in the urethra meatus (urinary opening) in male children. Due to the postoperative pain, symptoms such as discomfort, agitation, and restlessness are generally found. In particular, young children with restlessness often express their pain or discomfort with their bodies because they are unable to express it in words. This severe restlessness may make an operated region unstable, accompanying bleeding, infection, or other surgery-related complications. Because postoperative pain control is very important, neuraxial block techniques such as epidural block or caudal block have been employed in addition to a penile dorsal nerve block. Although the neuraxial block technique including the caudal block is an easy and safe method and has an excellent effect, the neuraxial block technique poses a potential risk in the procedure. In addition, with respect to the surgical prognosis, it has been reported that penile engorgement may cause penile vasodilation, resulting in oozing at the surgical region or other surgical complications. However, there has not been a report on the increase of postoperative complications by penile vasodilation or on the difference in the recovery or surgical prognosis according to the types of pain control for young patients.

NCT ID: NCT02162810 Terminated - Hypospadias Clinical Trials

Effect of Steroids on Post-Operative Complications Following Proximal Hypospadias Repair

Start date: May 2014
Phase: N/A
Study type: Interventional

The primary objective of this study is to determine the efficacy of administering a course of postoperative oral steroids in pediatric patients undergoing proximal hypospadias repair as prevention against complications. Specifically, the study aims to assess if the steroids i) decrease the incidence of wound breakdown, fistula formation, stenosis or stricture formation, and the need for subsequent redo-hypospadias surgeries and/or fistula repairs and ii) improve the quality of wound healing including the overall cosmetic appearance of the phallus (i.e. location of the urethral meatus).

NCT ID: NCT02103712 Completed - Hypospadias Clinical Trials

Long Term Outcome of Hypospadias Repair

Start date: October 1, 2012
Phase:
Study type: Observational

Hypospadias is a common congenital abnormality of the penis which affects approximately 1 boy in 250. The opening of the urethra is located on the undersurface of the penis rather than the tip,the foreskin is deficient and there is curvature of the penile shaft in more severe cases. Although the most commonly practised corrective operation ( TIP procedure) gives generally good results, recently published evidence points to a possible long term risk of stenosis ( narrowing of the reconstructed urethra). This comparative study will combine clinical assessment with non invasive measurements of urinary flow to assess the functional outcome of a large series of patients who have undergone hypospadias surgery . The study is primarily designed to answer this question : does a modification of the standard operation which incorporates a skin graft into the reconstructed urethra lead to improved urinary flow and a decreased risk of stenosis? This has not been previously studied . The findings of our study could make an important contribution to improvements in the surgical treatment of boys born with hypospadias.

NCT ID: NCT02096159 Active, not recruiting - Hypospadias Clinical Trials

Prophylactic Antibiotics or Placebo After Hypospadias Repair

PROPHY
Start date: March 2014
Phase: N/A
Study type: Interventional

The primary purpose of this study is to determine if routine use of prophylactic (preventive) antibiotics after repair of mid-to-distal hypospadias is beneficial.

NCT ID: NCT02040389 Completed - Anxiety Clinical Trials

Visual Guidelines and Tutoring in Pediatric Urological Surgery

Start date: March 2014
Phase: N/A
Study type: Interventional

The aim of this study is checking impact of visual guidelines (picture book) and tutoring in pediatric urologic surgery