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Hypoperfusion clinical trials

View clinical trials related to Hypoperfusion.

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NCT ID: NCT05953142 Not yet recruiting - Sepsis Clinical Trials

Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation.

DEEP
Start date: February 1, 2024
Phase: Phase 2
Study type: Interventional

This phase 2 study aim to investigate the effect of dobutamine in patients with sepsis/ septic shock after fluid resuscitation and with hypoperfusion (lactate and central venous oxygen saturation or prolonged capillary refill time) on renal function as compared with usual care.

NCT ID: NCT05582824 Recruiting - Metabolism Clinical Trials

Lactate Metabolism in the Hypoperfused Critically Ill

Start date: September 15, 2022
Phase:
Study type: Observational

Investigating lactate metabolism in critically ill patients whom are hypoperfused by preforming metabolomics via liquid chromatography-mass spectrometry.

NCT ID: NCT05499624 Terminated - Hypoperfusion Clinical Trials

POMCO2 Clinical Study MicroTrend System pCO2 Sensor

Start date: November 22, 2022
Phase: N/A
Study type: Interventional

The objective of this non-significant risk (NSR) study is to evaluate the safety and efficacy of the MicroTrend System by correlating POMCO2 data with relevant clinical metrics including arterial pressure and heart rate.

NCT ID: NCT05145049 Completed - Brain Tumor Clinical Trials

The Relationship of Anesthesia Method With Serum Lactate Level in Craniotomies

Start date: November 1, 2021
Phase:
Study type: Observational [Patient Registry]

The investigators aimed to research the incidence of hyperlactatemia in craniotomy cases, the relationship of lactate elevation with tumor type and other factors that may be related, and whether the general anesthesia method applied (inhalation anesthesia or total ıntravenous anesthesia) affects lactate level.

NCT ID: NCT04538079 Terminated - Clinical trials for Hemodynamic Instability

Non-invasive Objective Assessment of Hemodynamics in Preterm Neonates

NOAH
Start date: November 9, 2019
Phase:
Study type: Observational

Study type: Prospective Observational trial Study design: Longitudinal Population: Preterm newborns <32 weeks gestational age Hypothesis: The inclusion of non-invasive physiological measures of cardiac output, peripheral perfusion and brain oxygenation (NIRS) for preterm neonates is feasible and reveals additional information on the hemodynamic status compared to blood pressure alone. These measurements can improve the ability to rapidly identify those infants who might benefit from intervention and are correlated with short term clinical outcomes.

NCT ID: NCT04198168 Terminated - Acute Kidney Injury Clinical Trials

The Predictive Performance of Renal Ultrasound on Changes in Renal Clearance

Start date: January 1, 2020
Phase:
Study type: Observational

The study will examine the ability of renal ultrasound (Doppler and Contrast Enhanced Ultrasound (CEUS)) in distinguishing ICU patients who exhibit increases in glomerular filtration rate (GFR) in response to fluid loading, from those for whom fluid loading is without benefit of directly harmful.

NCT ID: NCT04166331 Recruiting - Sepsis Clinical Trials

Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion

ADAPT
Start date: September 20, 2020
Phase: Phase 3
Study type: Interventional

Sepsis induces both a systolic and diastolic cardiac dysfunction. The prevalence of this septic cardiomyopathy ranges between 30 and 60% according to the timing of assessment and definition used. Although the prognostic role of septic cardiomyopathy remains debated, sepsis-induced left ventricular (LV) systolic dysfunction may be severe and associated with tissue hypoperfusion, while it appears to fully recover in survivors. Accordingly, optimization of therapeutic management of septic cardiomyopathy may contribute to improve tissue hypoperfusion in increasing oxygen delivery, and to reduce related organ dysfunctions in septic shock patients. Echocardiography is currently the recommended first-line modality to assess patients with acute circulatory failure. Current Surviving Sepsis Campaign strongly recommends Norepinephrine as the first-choice vasopressor in fluid-filled patients with septic shock. In contrast, the use of Dobutamine is only suggested (weak recommendation, low quality of evidence) in patients with persistent tissue hypoperfusion despite adequate fluid resuscitation and vasopressor support. Levosimendan, an alternative inodilator, has failed preventing acute organ dysfunction in septic patients and has induced more supraventricular tachyarrhythmias than in the control group. Data supporting Dobutamine in this setting are scarce and primarily physiologic and based on monitored effects of this drug on hemodynamics and indices of tissue perfusion. No randomized controlled trials have yet compared the effects of Dobutamine versus placebo on clinical outcomes. In open-labelled, small sample trials, the ability of septic patients to increase their oxygen delivery during Dobutamine administration appears to be associated with lower mortality. The tested hypothesis in the ADAPT trial is that Dobutamine will reduce tissue hypoperfusion and associated organ dysfunctions in patients with septic shock and associated septic cardiomyopathy. In doing so, it may participate in improving clinical outcomes.

NCT ID: NCT02846727 Withdrawn - Hypoperfusion Clinical Trials

Using Fluorescence Angiography to Detect Occult Shock

Start date: August 2016
Phase: N/A
Study type: Observational

The purpose of this study is to determine if fluorescence angiography can detect occult shock (hypoperfusion).

NCT ID: NCT01272843 Not yet recruiting - Clinical trials for Transient Ischemic Attack

Physiological Magnetic Resonance Imaging (MRI) to Improve Carotid Endarterectomy Outcomes

Start date: February 2011
Phase: N/A
Study type: Observational

The carotid arteries are blood vessels in the neck that supply blood to the brain. Carotid stenosis disease is defined as a narrowing of these arteries due to the build up of plaque. The plaque material can also break off and move into the brain. The resulting blockage of blood supply to a portion of the brain is what causes 80% of all strokes. One treatment option is to have surgery on the carotid artery and remove the plaque. This procedure is called a carotid endarterectomy (CEA). There is evidence that proves CEA reduces the risk of stroke. The objective of this research project is to determine who is most likely to benefit from CEA surgery.

NCT ID: NCT01239303 Enrolling by invitation - Hypoperfusion Clinical Trials

Effects of Citrulline on Gut Functioning During Excercise

Start date: December 2010
Phase: N/A
Study type: Interventional

During exercise, splanchnic perfusion is compromised, resulting in organ damage in healthy individuals. Improving the availability of NO might result increase splanchnic perfusion and prevent organ damage during exercise.