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Hypolipoproteinemia clinical trials

View clinical trials related to Hypolipoproteinemia.

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NCT ID: NCT00362180 Completed - Clinical trials for Hypercholesterolemia

Measure Liver Fat Content After ISIS 301012 (Mipomersen) Administration

Start date: July 2006
Phase: Phase 2
Study type: Interventional

This study will assess what, if any, effect that ISIS 301012 (mipomersen) has on liver triglyceride content in multiple groups of subjects with varying degrees of risk for hepatic steatosis. In order to enroll subject groups with varying degrees of risk, the study has included multiple cohorts (Cohorts A-G). Additions and removal of cohorts has been accomplished with protocol amendments.

NCT ID: NCT00298909 Completed - Coronary Disease Clinical Trials

Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low High-Density Lipoproteins (HDL)

Start date: March 2006
Phase: Phase 4
Study type: Interventional

The investigators want to study the relative effects of physical exercise vs. extended-release niacin (lipid-lowering drug) in patients with coronary heart disease and low HDL cholesterol ("good cholesterol") on - lipid profile - endothelial function as measured by ultrasound The endothelium is the inner part of the blood vessels. Impaired endothelial function is known to be associated with atherosclerosis which can ultimately lead to diseases such as stroke, heart attack and others. Endothelial function can be assessed non-invasively by ultrasound. Both interventions mentioned above have been shown to have a beneficial effect on lipid profile and endothelial function. However, the relative effects are unclear.

NCT ID: NCT00001154 Completed - Clinical trials for Hypercholesterolemia

Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Start date: September 3, 1976
Phase:
Study type: Observational

Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in the blood. This study is designed to improve understanding of normal, as well as abnormal, lipoprotein metabolism and the role it plays in the development of hardening of the arteries (atherosclerosis). Patients participating in this study will receive injections of lipoproteins or apolipoproteins (the protein component of lipoproteins) that have been isolated and purified. These lipoproteins will be labeled with small amounts of radioactive material and sterilized before they are injected into the patient. Patients participating in the study will be required to have blood samples taken, and provide urine samples throughout the course of the study. In addition, patient will be required to follow a specially formulated diet. Patients will be weighed throughout the course of the study.