View clinical trials related to Hypoalphalipoproteinemia.
Filter by:Individuals with reduced plasma concentration of high-density lipoprotein (HDL) cholesterol are more susceptible to oxidative stress and often present reduced endothelial function, which has been mainly related to this susceptibility. Studies in animal and cell models have demonstrated that niacin activates both GPR-109A in leukocytes and heme oxygenase-1 (HO-1) pathway promoting strong anti-inflammatory and anti-oxidative effects. . In this context, the aim of this study was to investigate the short-term effect of niacin on endothelial function and verify the existence of interaction of PGD2 receptor antagonist, i.e. laropiprant (LRPT), in subjects with low HDL-cholesterol (HDL -C).
- This is a randomized, open-label, single blind, clinical trial - The study evaluated the effect of tomato consumption in serum HDL-cholesterol levels. - The hypothesis was that two daily tomatoes during one month will increase the HDL-c levels. - Since a placebo of tomatoes cannot be done, the control group will receive same proportion of cucumber because 1) it was not possible to have a tomato placebo; 2) cucumber does not have any lycopene; 3) both can be prepared similarly; and 4) the required quantity can be measured in the same way. - The intervention was during 1 month and was assigned by randomization. - Personnel who did the clinical and biochemical evaluation were blinded for the intervention. - Lipid profile was measured before and after the intervention. - Confounding factors such as daily physical activity, diet, consumption of fish or alcoholic beverages, smoking status were considered during statistical analyses.