Dopamine & Muscle Function in the Heat

Status Active, not recruiting

Clinical Trial Summary

our goal is to study the effects of dopamine activity, using Ritalin ingestion, on neuromuscular function over the course of a progressive heating and cooling protocol developed in our lab. We hypothesize that Ritalin will minimize the previously reported progressive impairment in neuromuscular function with hyperthermia compared to placebo, suggesting that dopamine activity preserves neuromuscular capacity with hyperthermia.

Clinical Trial Description

Increased core temperature (hyperthermia) has been associated with impaired neuromuscular performance, with the majority of research suggesting that the observed fatigue is related to the central nervous system. Small doses of Ritalin has been used to study how changes in dopamine activity affects exercise capacity in the heat. This study found that 20 mg of Ritalin had no effect on exercise capacity in a thermoneutral environment of 18°C. However, when in a hot (30°C) environment, the Ritalin resulted in a 16% improvement in finishing time compared to the placebo trial. Interestingly, the higher output during the Ritalin-hot condition also resulted in higher rates of heat production and a higher (~0.6°C) core temperature, suggesting that dopamine enabled greater voluntary tolerance of hyperthermia. This matches recent work from our own work showing that motivational skills training increased both exercise tolerance and final core temperature, and it is possible that dopamine activity played a role in this improvement. Ultimately, fatigue is shown in an inability to sustain muscular force. However, the role of dopamine activity on neuromuscular function (e.g., central activation and recruitment of muscle) during hyperthermia is unknown. One study reported that 20 mg of Ritalin did not alter neuromuscular function, but this study was done without thermal stress. Therefore, our goal is to study the effects of dopamine activity, using Ritalin ingestion, on neuromuscular function over the course of a progressive heating and cooling protocol developed in our lab. We hypothesize that Ritalin will minimize the previously reported progressive impairment in neuromuscular function with hyperthermia (5, 7) compared to placebo, suggesting that dopamine activity preserves neuromuscular capacity with hyperthermia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03515668
Study type	Interventional
Source	Brock University
Contact
Status	Active, not recruiting
Phase	N/A
Start date	April 20, 2018
Completion date	December 31, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04431596` - Military Alerting System for Monitoring Body Temperature During Active Cooling	N/A
Completed	`NCT05601713` - Mitigating Heat-induced Physiological Strain and Discomfort in Older Adults Via Lower Limb Immersion and Neck Cooling	N/A
Completed	`NCT00940654` - The Fever and Antipyretic in Critically Illness Evaluation Study	N/A
Active, not recruiting	`NCT05809453` - Intranasal Cocaine and Temperature Regulation During Exercise	Phase 1/Phase 2
Completed	`NCT04915859` - Semiconductor Heat Extraction Cooling	N/A
Completed	`NCT04613843` - Cold Water Immersion Stirring in Hyperthermic Individuals	N/A
Completed	`NCT03689478` - Use of Immediate Hyperthermic Intravesical Chemotherapy Following TURBT	N/A
Completed	`NCT02271607` - The Effect and Safety of Moxibustion Therapy for Overactive Bladder Patients	N/A
Terminated	`NCT01963117` - Effectiveness of the Combined WLI and Hyperthermia for GI Cancer Liver Metastasis	N/A
Completed	`NCT04596618` - Impact of ICE on Exercise Performance in the Heat	N/A
Withdrawn	`NCT05710978` - Biomarkers to Assess Acute Kidney Injury Risk During Heat Strain	N/A
Completed	`NCT05586477` - Diphenhydramine and Sweating	Phase 4
Completed	`NCT01576822` - Sauna Detoxification Study: Pilot Feasibility	Phase 1
Recruiting	`NCT05366270` - Peripheral Neuroimmune Mechanisms of Hyperthermia	N/A
Recruiting	`NCT05993910` - Prospective Hyperthermia Database in Cancer Patients (HT Register)
Terminated	`NCT04104334` - Impact of an Optimised Monitored Anesthesia on the Patients' Recovery After Cytoreduction Surgery Plus HIPEC	N/A
Not yet recruiting	`NCT06389604` - Preparing for Heat Waves - Enhancing Human Thermophysiological Resilience	N/A
Not yet recruiting	`NCT05274009` - Protective Cooling Measures to Safeguard Elderly People From Dangerous Summer Heat	N/A
Terminated	`NCT00796900` - Dantrolene for Treatment of Hyperthermia in Subarachnoidal Hemorrhage (SAH)	Phase 2/Phase 3
Active, not recruiting	`NCT02546596` - The Effect of Electro-Hyperthermia in Preoperative Radiotherapy for Locally Advanced Rectal Cancer	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Dopamine and Muscle Function in the Heat

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms