Hypersensitivity, Immediate Clinical Trial
Official title:
Cellular Inflammation Characterization of Nasal Challenges With Fine and Ultrafine Particles
The goal of this study is to see how the type and size of particles found in air pollution affects inflammation in the nose in people who are skin test positive to at least one allergen. It has been observed that pollution makes allergies worse. It has also been suggested that very small particles may affect allergies more than larger particles.
Cough, bronchitis, asthma, and chronic obstructive pulmonary disease are all associated with
elevated pollution particle levels. Researchers believe that particulate pollutants can
exacerbate allergy and inflammation and affect asthma and allergy prevalence. In an urban
setting such as the Los Angeles Basin, particles generated by vehicular traffic are thought
to be important risk factors. Recently, the Environmental Health Centre of Southern
California confirmed that there is a strong association between traffic near homes and
schools and development of asthma. This study will help researchers describe the effects of
various size pollution particles in causing inflammation in the nose.
There will be a total of 20 study visits. The study procedures include physical exams,
symptom score for nose, nose washes and nose challenges with particulate matter. The
particulates will be given in a random order and include the following: saline (sterile salt
water), inert carbon particles (Carbon Black), diesel exhaust particles (DEP), small (fine)
particles or very small (ultrafine) particles. These last two (fine and ultrafine) particles
are obtained from concentrated normal Los Angeles air. The particulate will be sprayed into
the nose with a standard nasal spray.
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Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject)
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