RCA for CRRT in Hyperlactatemia Patient With Increased Bleeding Risk

Status Not yet recruiting

Clinical Trial Summary

The purpose of this single center, randomized, control, open-labeled study is to evaluate the effect and safety of RCA versus no anticoagulation for CRRT in hyperlactatemia patients with increased bleeding risk.

Clinical Trial Description

For continuous renal replacement therapy (CRRT) patients with shock and muscle hypoperfusion, which characterised by tissue hypoxia and hyperlactatemia, the Kidney Disease Improving Global Outcomes (KIDIGO) guideline recommended no use of regional citrate anticoagulation (RCA) considering the potential increased citrate accumulation (CA) risk. In the condition of increased bleeding, no-anticoagulation was recommended for these patients. However, CRRT processed without anticoagulation was proved to be associated with shorter filter lifespan. Therefore, the purpose of this single center, randomized, control, open-labeled study is to evaluate the safety and efficacy of RCA versus no-anticoagulation for CRRT in hyperlactatemia patients with increased bleeding risk. ;

Study Design

Related Conditions & MeSH terms

Bleeding
Continuous Renal Replacement Therapy
Hemorrhage
Hyperlactatemia

Clinical Trial Details

NCT number	NCT04315623
Study type	Interventional
Source	Fourth Military Medical University
Contact	Ming Bai, MD
Phone	+86029-84775197
Email	mingbai1983@126.com
Status	Not yet recruiting
Phase	N/A
Start date	March 30, 2020
Completion date	March 3, 2022

View Details

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