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Hyperkalemia clinical trials

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NCT ID: NCT06281470 Completed - Hyperkalemia Clinical Trials

The Safety and Tolerability of WS016 in Healthy Chinese Volunteers

Start date: February 13, 2023
Phase: Phase 1
Study type: Interventional

This clinic trial evaluates the safety and tolerability of single- and multiple- ascending doses of WS016 in healthy adult participants. There will be about 64 participants,48 active and 16 placebo.

NCT ID: NCT05860491 Completed - Hyperkalemia Clinical Trials

Dietary Fiber and Hyperkalemia in Dialysis Patients

Start date: January 1, 2022
Phase:
Study type: Observational

To analyze the dietary nutrition and dietary fiber (DF) intake of maintenance hemodialysis (MHD) patients, and explore the effect of dietary nutrition and DF intake balance on the nutritional status and pre-dialysis hyperkalemia of MHD patients.

NCT ID: NCT05535920 Completed - Hyperkalemia Clinical Trials

A Prospective, Randomized, Open-Label, Cross-Over Study of Lokelma to Control Interdialytic Hyperkalemia

ADAPT
Start date: April 14, 2022
Phase: Phase 4
Study type: Interventional

A Prospective, RanDomized, Multi-Center, Open-Label, Cross-Over Study of Sodium Zirconium Cyclosilicate to Control Interdialytic HyperkalemiA Following Augmentation of Dialysate Potassium: Efficacy to Reduce the Incidence of Post-Dialysis Atrial Fibrillation and Clinically SignificanT Cardiac Arrhythmias - ADAPT Trial

NCT ID: NCT05462119 Completed - Hyperkalaemia Clinical Trials

Safety of Oral Resin for Treatment of Hyperkalemia in Chinese Patients With Renal Insufficiency

SCRUTINIZE
Start date: August 22, 2022
Phase:
Study type: Observational

It is a multicenter, prospective, non-interventional cohort study, in order to evaluate the safety of oral resin for treatment of hyperkalemia in Chinese patients with renal insufficiency.

NCT ID: NCT05441852 Completed - Hyperkalemia Clinical Trials

A Study to Detect Hyperkalemia Using Smartphone-enabled Electrocardiogram (EKG)

REACT
Start date: March 31, 2022
Phase:
Study type: Observational

The purpose of this study is to validate the real-world performance of a previously developed Artificial Intelligence - Electrocardiogram (AI-ECG) algorithm for identification of hyperkalemia with a six-lead mobile-enhanced device .

NCT ID: NCT05382988 Completed - Hyperkalemia Clinical Trials

Sodium Zirconium Cyclosilicate Lowers Hyperkalemia After Parathyroidectomy

SZC
Start date: November 2016
Phase: Phase 3
Study type: Interventional

Sodium zirconium cyclosilicate (SZC) has been demonstrated for its serum potassium-lowering efficacy and safety in hyperkalemia hemodialysis patients. However, the effects of SZC during the perioperative period remained unknown. This experiment aimed to determine whether using SZC would impact the serum potassium levels in patients with maintenance hemodialysis after parathyroidectomy (PTX).

NCT ID: NCT05271266 Completed - Hyperkalaemia Clinical Trials

A Multicenter, Prospective, Non-interventional Cohort Study to Evaluate the Safety and Treatment Pattern of Sodium Zirconium Cyclosilicate for Hyperkalaemia Management in Real World Practice in China

ACTUALIZE
Start date: March 22, 2022
Phase:
Study type: Observational

The study is a multi-center prospective (primary data) non-interventional cohort study which enrolls 1500 patients including new and ongoing users on SZC at Study Enrollment Day in real-world clinical practice. The eligible study patients will be identified by physicians in each study site by assessing the patients or reviewing the medical record. The prescription (including initiation, dose-adjusting or interruption) or discontinuation of SZC will be determined by physicians as per real-world clinical practice and in accordance with the local label. Any AZ employee, or member of the research operation team must not intervene in the decision-making of any physician or patient through any approach, at any time during the study. Every patient will be followed up according to standard clinical practice for 6 months from enrolment.

NCT ID: NCT05184998 Completed - Heart Failure Clinical Trials

Description of the Clinical Outcomes of Hospitalized Patients With Heart Failure With Different Serum Potassium Levels

SPLENDID
Start date: November 30, 2021
Phase:
Study type: Observational

China National Heart Failure Registration Study (CN-HF) is a nationwide, hospital-based, multicentre, prospective registry study sponsored by Ministry of Science and Technology of the People's Republic of China. It is aimed to understand the etiology, clinical features and treatments of in-hospital HF patients in China [3]. At present, there are few studies to describe the clinical outcomes of HF patients with different sK levels in China. Utilizing the CN-HF database, this study is aimed to describe the sK levels of hospitalized HF patients and its impact to the clinical outcomes of patients.

NCT ID: NCT05118022 Completed - Hyperkalemia Clinical Trials

Artificial Intelligence Identified Dyskalemia Using Electrocardiogram (AIDE)

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

This is a randomized controlled trial (RCT) to test a novel artificial intelligence (AI)-enabled electrocardiogram (ECG)-based screening tool for improving the diagnosis and management of potassium abnormalities.

NCT ID: NCT05029310 Completed - Kidney Transplant Clinical Trials

Effects of Patiromer on Pharmacokinetics of Immunosuppresive Drugs in Renal Transplant Recipients

TACPAT
Start date: September 1, 2021
Phase: Phase 4
Study type: Interventional

Patiromer lowers potassium effectively in patients with hyperkalemia and chronic kidney disease. Patients with a kidney transplant usually have reduced renal function and may also develop hyperkalemia. However, potential interactions between immunosuppressive medications and patiromer have not been evaluated. These interactions could involve change in AUC of immunosuppressive drugs, such as calcineurin inhibitors or mycophenolate, or increased risk of hypomagnesemia, since both tacrolimus and patiromer have this potential side effect. We wish to evaluate potential interactions to ensure safe use of this drug in the transplant population.