Effects of Coffee Roasting on Blood Sugar Levels in Healthy Humans

Hyperglycemia Clinical Trial

Official title:

Effects of Coffee Roasting on Blood Sugar Levels in Healthy Humans

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05119153
• Other study ID #: 16857
• Status: Completed
• Phase: N/A
• Start date: November 5, 2019
• Est. completion date: October 31, 2021

Study information

• Verified date: November 2021
• Source: North Carolina State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The present study determined the effects light, medium, and dark roasted, brewed coffees on blood glucose responses in normal (n = 19) subjects.

Description:

This is a single-blinded, randomized partial block design conducted over 6 weeks in two parts.

In part 1 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a beverage containing 50 g of glucose.

In part 2 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a standardized breakfast (corn flakes cereal + skim milk) containing 50 g of glucose.

In each part, fasting and postprandial glucose profiles were determined.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Est. completion date: October 31, 2021
• Est. primary completion date: December 20, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl.

Exclusion Criteria:

• Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl.

• Weight less than 110 pounds (55 kg)

• Pre-existing health conditions, such as:

• High cholesterol

• Hypertension

• Cardiovascular disease

• Gastrointestinal motility disorders

• Hypo- or hyperthyroidism

• Anemia

• Renal disease

• Liver disease, including hepatitis B or C, cholestasis, cirrhotic liver disease, or non-alcoholic fatty liver disease

• Chronic or acute pancreatitis

• Diabetes type 1 or 2

• Insulin resistance

• Polycystic ovary syndrome

• Food allergies or intolerances to coffee/caffeine/dairy/corn-based cereals.

• Currently taking prescription medication

• Current smoker

• Consumes more than 3 alcoholic beverages per day

• Pregnant or breastfeeding

• Not willing to take their own blood samples with finger sticks

Related Conditions & MeSH terms

• Hyperglycemia

Intervention

Dietary Supplement:
• Placebo Comparator
Placebo designed to mimic coffee color.
• Light Roasted Coffee
12 oz light roast coffee
• Medium Roasted Coffee
12 oz medium roast coffee
• Dark Roasted Coffee
12 oz dark roast coffee

Locations

Country	Name	City	State
United States	Schaub Hall, Campus Box 7624	Raleigh	North Carolina

Sponsors (1)

Lead Sponsor	Collaborator
North Carolina State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in Blood Glucose	Each week, fasted baseline and postprandial measurements taken out to 240 minutes	6 weeks
Secondary	Changes in Glucose Area Under the Curve	Used glucose changes over 240 minutes to construct area under the curve	6 weeks