Hyperglycemia, Exercise, and Endothelial Function

Hyperglycemia Clinical Trial

Official title:

Effect of Short-Term Glucose Loading on Vascular Function

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03651713
• Other study ID #: 201807752
• Status: Completed
• Phase: N/A
• Start date: October 15, 2018
• Est. completion date: October 21, 2019

Study information

• Verified date: March 2020
• Source: University of Iowa
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days. Subjects will be randomly assigned to either the glucose with (GLU+EX) or without (GLU) structured exercise group.

Description:

Acute (oral glucose tolerance test) and chronic (type 2 diabetes) hyperglycemia are associated with impaired endothelial function. Both a single bout of exercise and chronic exercise training are associated with improvements in vascular endothelial function. It remains unknown if exercise can preserve vascular endothelial function during hyperglycemia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: October 21, 2019
• Est. primary completion date: October 21, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Healthy young men 18-35 years of age.

Exclusion Criteria:

• Hypertension,

• Hyperlipidemia,

• Smoking,

• Heart disease,

• Chest pain upon exertion,

• Previous heart surgeries or history of arrhythmias,

• Diabetes,

• Obesity (body mass index =30kg/m2),

• Kidney disease,

• Pulmonary disease,

• Autonomic disorders,

• Individuals whom engage in structured exercise (=30min, =2d/wk),

• Current use of medications which influence outcome measures

Related Conditions & MeSH terms

• Endothelial Function
• Hyperglycemia

Intervention

Behavioral:
• GLU+EX
Subjects will complete 45 minutes of recumbent cycling at 60-65% of age-predicted maximal heart rate five times over seven days while ingesting a 75g glucose beverage three times daily.

Dietary Supplement:
• GLU
Subjects will consume a 75g glucose beverage three times daily over a seven-day period.

Locations

Country	Name	City	State
United States	Medical Education Building	Iowa City	Iowa

Sponsors (1)

Lead Sponsor	Collaborator
University of Iowa

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Physical Activity	Steps per day will be recorded via accelerometry throughout the intervention in both groups.	Continuously throughout the seven-day intervention.
Other	Caloric Consumption	Subjects will record their dietary intake throughout the intervention.	Continuously throughout the seven-day intervention.
Primary	Change in Vascular Endothelial Function	Brachial artery flow-mediated dilation (%), measured via Doppler ultrasound, will be assessed before and after the intervention.	Before and after the seven-day intervention in both groups.
Secondary	Central Blood Pressure	Aortic blood pressure will be derived from radial artery pressure wave measurements (via applanation tonometry) during resting conditions.	Before and after the seven-day intervention in both groups.