Hyperglycemia Clinical Trial
Official title:
The Influence of Sampling Site When Assessing Glucose Tolerance or Insulin Sensitivity With Oral Glucose Ingestion
For decades, it has been known that post-meal blood glucose concentrations were associated
with the risk of T2D, which was reflected in early diagnostic guidelines. The oral glucose
tolerance test (OGTT) has been used since at least 1923 and has remained the most common
test for assessing glucose tolerance. Arterial blood (or arterialised blood using heated
hand technique) is most appropriate for determining glucose tolerance and insulin
sensitivity since this best represents the concentrations of metabolites and hormones that
peripheral tissues are exposed to. It is essential to investigate whether venous blood
(sometimes used during an OGTT) is representative of arterialised blood during an OGTT, and
under different metabolic conditions.
The investigators want to understand whether OGTT-derived insulin sensitivity indices differ
from venous and arterialised blood; and 2) investigate whether metabolic status (i.e. rest
vs lower-limb exercise) influences the difference between forearm venous and arterialised
concentrations of glucose and insulin during an OGTT.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
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