Surgery--Complications Clinical Trial
Official title:
An Optimization in the Postoperative Treatment in Head and Neck--surgical Patients -- Improvement in Glycemic Control to Reduce the Incidence of Hyperglycaemia and Associated Complications.
Based on glycemic load (overall increase in blood glucose), it is investigated whether better
glycemic control (large fluctuations in blood glucose to abnormal values are attempted) can
improve the postoperative phase of head and neck surgical patients who receive Dexamethasone
(glucocorticoid). Furthermore it is examined whether this optimization in treatment can
result in reduced hospitalization time and fewer re-admissions.
Hypothesis:
Continuous blood glucose measurement and insulin therapy will optimize the postoperative
phase of the embedded head and neck patient receiving Dexamethasone by reducing the incidence
of hyperglycaemia and associated complications.
After surgical intervention, an insulin resistance condition will occur because of the
following stress response. This condition will for the majority of cases results in poor
glycemic control - and there will be a risk of hyperglycaemia in the hospitalized patient.
This condition affects all cells in the body and therefore has associated complications such
as bigger risk at multiple infections, longer healingprocess, poorer fluid balance, etc.
Hyperglycaemia is associated with a poorer outcome for the patient, which can cause an
increase in hospitalization days and multiple re-admissions. It is also common for the
postoperative patient to experience nausea and pain as a result of both surgery and
anesthesia and immobilization. To counter this, the patient receives Dexamethasone (steroid
treatment).
This experiment is based on the fact that there is still insufficient attention at this
postoperative insulin resistance. In a large randomized study from 2001(Van den Berghe),
insulin therapy was initiated for intensive patients. This study points out that even
moderate increases in blood glucose are associated with increased morbidity and that insulin
therapy is both capable of reducing mortality and morbidity.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05062564 -
Efficacy of LipiFlow in Patients Affected by Meibomian Gland Dysfunction in Reducing Post-cataract Surgery Dry Eye
|
N/A | |
Completed |
NCT05346588 -
THRIVE Feasibility Trial
|
Phase 3 | |
Completed |
NCT03930784 -
A Real-world Study to Examine the Relationship Between Simple Physical Functioning Tests, Complications and Recovery Following Abdominal Surgery.
|
||
Not yet recruiting |
NCT04430972 -
Immune Responsiveness and Outcome After Aortic Valve Surgery (Measure)
|
||
Recruiting |
NCT04887415 -
Respiratory Strength Training in Cardiac Surgical Patients
|
N/A | |
Recruiting |
NCT05254262 -
Multicenter National Trial of Clinical Results of Surgical Elderly Patients
|
||
Recruiting |
NCT03561376 -
Zinc Oxide Versus Petrolatum Following Skin Surgery
|
Early Phase 1 | |
Recruiting |
NCT05155878 -
Prognostic Factors in Periampullary Tumors and Cysts
|
||
Recruiting |
NCT04967391 -
Tumescence in HNC Skin Graft Reconstruction
|
Phase 3 | |
Terminated |
NCT03757455 -
ERAS Protocol in Pancreaticoduodenectomy and Total Pancreatectomy
|
N/A | |
Completed |
NCT03793816 -
Tonsillectomy Using BiZactâ„¢ - a Randomized Side-controlled Clinical Trial
|
N/A | |
Completed |
NCT03246165 -
Predictive Factors and Complications of Delirium
|
||
Withdrawn |
NCT04090918 -
Novel Methods for Characterizing Patients With Post-operative Atrial Fibrillation Secondary to Abdominal Surgery
|
||
Completed |
NCT05373238 -
Same Day Discharge After Laparoscopic Hysterectomy
|
||
Completed |
NCT03938584 -
The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients
|
N/A | |
Not yet recruiting |
NCT05046925 -
PACU for Postoperative Care After Major Thoracic and Abdominal Surgery
|
||
Completed |
NCT04550156 -
Evaluation of the Introduction of a Colorectal Bundle in Left Sided Colorectal Resections
|
N/A | |
Not yet recruiting |
NCT04199208 -
Does Prehabilitation Improve Outcome in Coloncancer Surgery?
|
N/A | |
Completed |
NCT04257344 -
Use of Wearables for Early Detection of Complications After Major Acute Abdominal Surgery
|
||
Active, not recruiting |
NCT03721471 -
Outcome of Very Old Patients Admitted for Elective Major Surgery, the Effect of Frailty
|