Investigation of the Glycemic Index of Ethiopian Honey

Status Enrolling by invitation

Clinical Trial Summary

The purpose of this study is to determine which of the Ethiopian honeys slowly/rapidly raise the blood glucose level.

Clinical Trial Description

The Addis Ababa University, College of Natural Sciences, Research Institutional Review Board (IRB) approved this study. Written consent forms were obtained from all 14 volunteers (7 females and 7 males). The subjects were randomly recruited from twenty eight 3rd year Food Science and Postharvest Technology students. People volunteering to participate in the study were excluded if they are: overweight, dieting, smoking, a family history of diabetes, pregnant, metabolic disorders, suffering from any illness or food allergy and regularly taking medication. The participants were checked for glucose tolerance according to the WHO (World Health Organization) classification (fasting glucose <7 mmol/L(millimole per lite) and 2-hour blood glucose concentration after a 25g glucose load <7.8 mmol/L). Ten (5 females and 5 males) were selected from fourteen using lottery sampling methods. Reference glucose and different honeys will be used as experimental foods. To determine the GI value, a portion of food containing 25 grams of available carbohydrate will be fed for ten healthy people in the morning after they have fasted for 11 hours overnight. After fasting blood sample will be obtained. The study participants will be consumed all honey or reference glucose served. Additional blood samples will be taken at 15, 30, 45, 60, 90 and 120 minutes after eating commenced. The two-hour blood glucose response for test food will be compared to the two-hour blood glucose response produced by pure glucose sugar. Glucose concentration in the seven blood samples was used to graph a two-hour blood glucose response curve. The area under two-hour blood plasma glucose response curve (AUC) for reference and test food was calculated by the trapezoidal rule and ANOVA (Analysis of Variance), using SAS (Statistical Analysis Software), 2002.

GI= AUCt/AUCr*100

Where:

AUCt = Area Under the Curve for honey; AUCr = Area Under the Curve for the reference glucose ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02488018
Study type	Interventional
Source	Addis Ababa University
Contact
Status	Enrolling by invitation
Phase	Phase 0
Start date	June 2015
Completion date	April 2016

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.