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Hypercholesteremia clinical trials

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NCT ID: NCT05164185 Completed - Clinical trials for Endothelial Dysfunction

The Effect of Remote Ischemic Conditioning in Patients With Hypercholesterolemia

Start date: September 2, 2020
Phase: N/A
Study type: Interventional

There is an on-going discussion weather remote ischemic conditioning (RIC) is effective in limiting the damage of reperfusion injury in STEMI patients. The results from recent RCTs have been variable and most have not shown convincing positive results when analyzing hard endpoints. Hence, there is a great need to evaluate the impact of comorbidities on the effectiveness of RIC. Therefore, we have designed a study to evaluate the impact of hypercholesterolemia on the RIC response by evaluating ischemia-induced endothelial dysfunction. Aim: To investigate the impact of hypercholesterolemia on the RIC response in counteracting ischemia-induced endothelial dysfunction.

NCT ID: NCT03634436 Completed - Hypercholesteremia Clinical Trials

The PK/PD Study of A Single Subcutaneous Injection of SHR-1209 in Healthy Subjects

Start date: August 30, 2018
Phase: Phase 1
Study type: Interventional

This is a Single Center, Randomized, Double-blind, Dose Escalation, Placebo Parallel Controlled PhaseⅠClinical study to Evaluate the Safety, Tolerability and Pharmacokinetics, Pharmacodynamics with A Single Subcutaneous Injection of SHR-1209 in Healthy Subjects. The primary objective of this study is to investigate the safety and tolerability of a range of subcutaneous SHR-1209 in healthy subjects. Secondary objectives are to determine the pharmacokinetics (PK) and pharmacodynamics(PD) profile of SHR-1209 in healthy subjects including assessment of immunogenicity.

NCT ID: NCT02850224 Completed - Obesity Clinical Trials

Pediatric Preventative Health Screenings - Obesity and Family-Centered Outcomes

Start date: April 20, 2017
Phase: N/A
Study type: Interventional

In 2012, an Expert Panel of the National Heart Lung and Blood Institute published guidelines on cardiovascular health and risk reduction in children; among these guidelines were screening recommendations for obesity and obesity-related conditions. Following publication of this report there was a call for caution and for increased patient (parent, child) input on implementing these guidelines. There are limited current studies evaluating patient-centered outcomes (PCO) in the well-child setting, however, given the childhood obesity epidemic, there is a clear need for such an evaluation. The city of Detroit, MI ranks first among 22 cities with data for the prevalence of overweight and obese youth (39.7%), making Henry Ford Health System, which is located in Detroit, MI, an ideal setting to study childhood obesity related research questions.

NCT ID: NCT02722408 Completed - Hypercholesteremia Clinical Trials

Efficacy and Safety of Gemcabene in Patients With Homozygous Familial Hypercholesterolemia on Stable, Lipid-Lowering Therapy (COBALT-1)

Start date: June 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study was to assess the efficacy, safety, and tolerability of multiple doses of Gemcabene in patients with HoFH on stable, lipid-lowering therapy.

NCT ID: NCT02634151 Completed - Hypercholesteremia Clinical Trials

A 12-Week, Phase 2 Study of Gemcabene in Hypercholesterolemia Patients on Stable Moderate and High-Intensity Statins

ROYAL-1
Start date: November 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study was to assess the efficacy, safety, and tolerability of multiple doses of gemcabene 600 mg QD compared to placebo in patients with hypercholesterolemia not adequately controlled on high-intensity or moderate-intensity stable statin therapy. Patients with HeFH, ASCVD, or otherwise uncontrolled, may be included with baseline LDL-C value ≥ 100 mg/dL. Subjects were randomized 1:1 to gemcabene 600 mg once daily (QD) or placebo.

NCT ID: NCT02587416 Completed - Hypercholesteremia Clinical Trials

Effect of Gemcabene on the Pharmacokinetics of Atorvastatin in Healthy Volunteers

Start date: November 2002
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine the effect of gemcabene on the pharmacokinetics of atorvastatin 80 mg

NCT ID: NCT01890889 Recruiting - Hyperlipidemia Clinical Trials

Study of Changes in Total Cholesterol Levels as a Function of Consuming a Supplement Designed to Improve Cardiovascular Health

AdBiotech
Start date: July 2013
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effectiveness of a food-source nutrient containing bitter orange by comparing changes 45 blood chemistries and self-reported quality of life.

NCT ID: NCT01477944 Completed - Hypercholesteremia Clinical Trials

Pattern of Statins Use in Catalonia

Start date: February 2012
Phase: N/A
Study type: Observational

To describe the new statins prescription pattern in Catalonia (getting their first prescription for any statin, or receiving a change in their statin treatment including switching, changing in doses or adding ezetimibe/fibrates) since September 2009.

NCT ID: NCT01354327 Completed - Hypercholesteremia Clinical Trials

Effects of Limicol on LDL-cholesterol

Start date: December 2008
Phase: N/A
Study type: Interventional

The principal objective of this study is to investigate the effects of a novel food supplement (Limicol) on LDL-cholesterol levels in healthy subjects with moderate hypercholesterolemia.

NCT ID: NCT00688454 Completed - Hypercholesteremia Clinical Trials

C-Control: Efficacy and Safety of Therapy With Rosuvastatin in Statin-Naive and in Statin-Switched Patients

Start date: February 2007
Phase: N/A
Study type: Observational

The study explores efficacy and safety of the lipid-lowering therapy with CRESTOR in statin-naive patients and in patients with previously unsuccessful statin therapy. This study was designed to investigate the dynamic of the lipid parameters and therapy tolerability during 8-10 weeks treatment with CRESTOR