Clinical Trials Logo
  1. Home
  2. Hypercapnic Respiratory Failure
  3. NCT02699112

Cardiac and Respiratory Function With Non-invasive Ventilation — CARE-NIV  

Hypercapnic Respiratory Failure Clinical Trial

Official title:
Improvement of Cardiac Function and Neural Respiratory Drive Following Set up of Non-invasive Ventilation in Patients With Hypercapnic Respiratory Failure Caused by Obesity Hypoventilation Syndrome

Clinical Trial Summary

To assess patients with hypercapnic respiratory failure using echocardiography,cardiac output measurements and markers of neural respiratory drive (EMGpara) prior to, during and after non-invasive ventilation (NIV) initiation, and to follow the patients for 3 months. The investigators hypothesize that the improvement in cardiac function and/or respiratory mechanics over time are associated with ongoing improvements in oxygenation, quality of life and exercise capacity.

Clinical Trial Description

Respiratory failure is characterized by the incapacity of the respiratory system to maintain the normal arterial blood gas homeostasis. Specifically, the overlap of hypoxaemia and hypercapnia (PaCO2 >6 kPa) is referred to as Hypercapnic Respiratory Failure (HRF). HRF is one of the most common causes for hospital admission with high re-admission rates, therefore constitute a major burden on healthcare systems. Non Invasive Ventilation (NIV) is a well established treatment in patients with hypercapnic respiratory failure who frequently suffer with associated pulmonary hypertension (PH). NIV helps to increase arterial oxygenation and reduces hypercapnia. It is used in patients with hypercapnic respiratory failure caused by Obesity Hypoventilation Syndrome (OHS). The associated degree of PH can lead to an increased afterload of the right ventricle (RV) that causes progressive remodelling of the right heart. RV dysfunction is correlated with a reduced long term prognosis in respiratory conditions. In literature NIV is shown as effective method to treat acute hypercapnic respiratory failure in OHS.

It has not been described how NIV impacts on cardiac function and NRD in OHS. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02699112
Study type Observational
Source Guy's and St Thomas' NHS Foundation Trust
Contact
Status Completed
Phase
Start date November 2015
Completion date March 2018
View Details
See also
  Status Clinical Trial Phase
Completed NCT02845076 - Weaning From Noninvasive Ventilation N/A
Recruiting NCT05008211 - Information-Motivation-Behavioral Skills Model-based Intervention to Domiciliary Non-invasive Ventilation of Patients N/A
Recruiting NCT03238339 - The Clinical Application and Popularization of Portable Home Noninvasive Ventilator
Recruiting NCT06047405 - NIV for Hypercapnic Respiratory Failure: AVAPS vs S/T BIPAP N/A
Completed NCT04108819 - Ketogenic Diet for Obesity Hypoventilation Syndrome N/A
Recruiting NCT02874339 - High Flow Nasal Oxygen Versus VNI in Acute Hypercapnic Cardiogenic Pulmonary Edema N/A
Not yet recruiting NCT05497986 - Conventional Low Flow Oxygenation Versus High Flow Nasal Cannula in Hypercapnic Respiratory Failure N/A
Completed NCT01987661 - The Effects of Airtrapping on Sleep and Breathing in Non Invasive Ventilation (NIV) in COPD N/A
Completed NCT03398239 - Comparison of BPAP ST/T and BPAP ST / T Mode With AVAPS for Hypercapnic Respiratory Failure in ED N/A
Terminated NCT03353064 - Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure N/A
Completed NCT04072848 - Mathematically Arterialised Testing of Hypercapnic Subjects Study
Not yet recruiting NCT04131660 - Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypoventilation N/A
Completed NCT01523470 - Withdrawal of Non-invasive Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Acute Hypercapnic Respiratory Failure Phase 3
Active, not recruiting NCT04709562 - Clinical Stabilization of Hypercapnia: NIPPV v HVNI N/A
Not yet recruiting NCT06064409 - Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
Recruiting NCT04351906 - Low-flow Extracorporeal Carbon Dioxide Removal in COVID-19-associated Acute Respiratory Distress Syndrome N/A
Not yet recruiting NCT06367686 - Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor
Completed NCT03406572 - Use of Nasal High Flow Oxygen During Breaks of Non-invasive Ventilation for Patients With Hypercapnic Respiratory Failure N/A
Active, not recruiting NCT03364946 - High Flow Therapy in ICUs Across Ibero America
Not yet recruiting NCT06257667 - Treatment of Acute Hypercapnic Respiratory Failure With OptiflowTM or Optiflow+DuetTM Nasal Cannula in COPD-patients N/A