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Hyperbilirubinemia clinical trials

View clinical trials related to Hyperbilirubinemia.

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NCT ID: NCT04182555 Completed - Jaundice, Neonatal Clinical Trials

Identification of Jaundice in Newborns Using Smartphones

Start date: August 3, 2020
Phase: N/A
Study type: Interventional

Neonatal jaundice is a common and most often harmless condition. However, when unrecognized it can be fatal or cause serious brain injury. Three quarters of these deaths are estimated to occur in the poorest regions of the world. The treatment of jaundice, phototherapy, is in most cases easy, low-cost and harmless. The crucial point in reducing the burden of disease is therefore to identify then children at risk. This results in the need for low-cost, reliable and easy-to-use diagnostic tools that can identify newborns with jaundice. Based on previous research on the bio-optics of jaundiced newborn skin, a prototype of a smartphone application was developed and tested in a pilot study and the application refined. This smartphone application will now be evaluated in a clinical trial set in two hospitals in Norway. The smartphone application gives immediate estimates of bilirubin values in newborns, and these estimates will be compared to the bilirubin levels measured in standard blood samples, as well as the results from ordinary transcutaneous measurement devices.

NCT ID: NCT03945942 Completed - Clinical trials for Liver Transplant; Complications

Influence of Hyperbilirubinaemia on Two Different Near Infrared Spectroscopy Devices

NIRS_GREFFE
Start date: March 15, 2019
Phase: N/A
Study type: Interventional

Protocol Near infrared spectroscopy liver transplants: comparison of two monitoring of Near infrared spectroscopy in pediatric liver transplant.

NCT ID: NCT03927833 Recruiting - Premature Infant Clinical Trials

Cycled Phototherapy

Start date: July 15, 2020
Phase: N/A
Study type: Interventional

Cycled phototherapy (PT) is likely to increase survival over that with continuous PT among extremely premature infants (< 750 g BW or <27 weeks GA).

NCT ID: NCT03880591 Completed - Clinical trials for Neonatal Hyperbilirubinemia

Neonatal Hyperbilirubinaemia in the Democratic Republic of Congo

Start date: March 7, 2019
Phase:
Study type: Observational

Neonatal hyperbilirubinaemia (NH) is common among healthy neonates and normally resolves within a week. Untreated pathological hyperbilirubinaemia, however, can result in long-term neurological sequelae, which compromise childhood development, or may result in perinatal death. True population-based data from middle to low-income countries are scarce and NH contribution to morbidity and mortality remains unclear. With this study the investigators aim at assessing the prevalence of neonatal hyperbilirubinaemia in a cohort of newborns in a maternity hospital in Kinshasa, the Democratic Republic of Congo, and at evaluating the possible risk factors for NH in the mother and the baby.

NCT ID: NCT03876678 Recruiting - Clinical trials for Hyperbilirubinemia, Neonatal

The Efficacy of Oral Probiotics on Neonatal Hyperbilirubinemia

Start date: May 24, 2019
Phase: N/A
Study type: Interventional

This trial will be carried out in two stages in the sick baby room of the Children's Hospital of China Medical University (CMUH). The first stage is: the enzyme active reaction kit (usually called API ZYM kit) was used to determine the β-glucuronidase activity of 9 strains of Lactobacillus and 4 strains of Bifidobacterium, screening out the probiotics that have the best inhibitory efficacy of intestinal β-glucuronidase activity; The second stage is: using the results of the first stage analysis, treating the newborns of jaundice by oral probiotics.

NCT ID: NCT03866213 Recruiting - Jaundice, Neonatal Clinical Trials

Validation of a Jaundice Diagnostic and Monitoring Device for Low-Resource Settings

Start date: August 1, 2019
Phase:
Study type: Observational

A team of researchers at Rice University in partnership with clinicians at Queen Elizabeth Central Hospital created BiliSpec, a low-cost battery-powered reader designed to immediately quantify serum bilirubin levels from a small drop of whole blood applied to a lateral flow strip. The simple and affordable BiliSpec system offers a faster and more cost-effective means to detect neonatal jaundice in under-resourced clinics and determine when phototherapy is needed. The goal of this study is to validate the accuracy of the BiliSpec device in measuring bilirubin levels in neonates relative to the laboratory spectrophotometric bilirubinometer and transcutaneous bilirubinometer measurements.

NCT ID: NCT03824990 Completed - Quality Improvement Clinical Trials

Multi-center Clinical Study on Neonatal Hyperbilirubinemia

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

Eight hospitals in China will participate in the study, which aims to decrease the incidence of severe hyperbilirubinemia.

NCT ID: NCT03741803 Suspended - Jaundice, Neonatal Clinical Trials

Relationship Between Delayed Cord Clamping at Birth and Neonatal Bilirubin Levels in Parturients With a Prior Child Requiring Therapy for Neonatal Jaundice

Start date: November 9, 2018
Phase: N/A
Study type: Interventional

The purpose of the study is to determine if neonates (who already have an increased risk of hyperbilirubinemia due to mother's history of having previous neonate who received phototherapy for hyperbilirubinemia) have higher bilirubin levels 24 hours after birth with delayed cord clamping.

NCT ID: NCT03723005 Completed - Clinical trials for Hyperbilirubinemia, Neonatal

A Light Emitting Diode (LED) Mattress for Phototherapy of Jaundiced Newborns

Start date: May 1, 2018
Phase:
Study type: Observational

The new investigational and FDA-approved device is named "SkyLife" and is a mattress, which uses blue LEDs as the light source similar to those used in the currently-used overhead blue LED panel devices.

NCT ID: NCT03684499 Not yet recruiting - Bilirubinemia Clinical Trials

Fluid in Neonatal Hyperbilirubinemia

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Hyperbilirubinemia is a common neonatal problem. bilirubin is potentially toxic to central nervous system and can cause serious permanent complication called kernicterus, in which brain stem nuclei and basal ganglia are damaged,resulting in cerebral palsy.In Hyperbiliubinemia,rapid reduction of serum bilirubin level is of utmost importance. Two commonly used mode of therapy are phototherapy and exchange transfusion. Phototherapy has some side effects such as diarrhea, skin rash, dehydration, overheating, mother-baby bonding disruption.On the other hand, complication of exchange transfusion include infections, emboli,anemia,apnea and hypocalcemia. while IV fluid supplementationis postulated to decrease bilirubin concentration directly through a reduction of haemoconcentration, increasing enteral feed volume is proposed to decrease bilirubin concentration through reduced enterohepatic circulation via an increased gut peristalsis.