Hyperalgesia Clinical Trial
Official title:
Dextromethorphan Effect on Central Sensitization to Pain in Healthy Volunteers
The aim of this study is to assess the anti-hyperalgesic effect of dextromethorphan in healthy volunteers compared to placebo.
This is a cross-over group, double-blind, randomized clinical trial in healthy volunteers
comparing dextromethorphan and inactive control on freeze-induced hyperalgesia, experimental
pain, diffuse noxious inhibitory control (DNIC), pupillary reaction and reaction time.
The influence of CYP3A4 and MDR1 polymorphism on the dextromethorphan analgesic efficacy
will be measured.
The study design is divided in two study sequences and each subject participates in the two
study sequences and receive the two treatments (dextromethorphan and placebo).
Each study sequence consists of 3 assessment days (Day -1, Day 0 = first treatment
administration and Day 1).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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