Hyperalgesia Clinical Trial
Official title:
Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans
This research study explores whether a beta-blocker (propranolol) can prevent a person from becoming more sensitive to pain after administration of an opioid (remifentanil). Beta blockers inhibit the sympathetic (fight or flight) response and are often used to treat angina and high blood pressure. In a previous study in human volunteers, the investigators demonstrated an increased sensitivity to pain after a 60-minute infusion of the opioid remifentanil. The goal of this study is to identify a possible inhibitor of this phenomenon.
Recent evidence suggests that opioid therapy may cause a biphasic response, i.e. initial pain
relief followed paradoxically by a longer lasting hypersensitivity to pain. Recent genetic
analysis in mice suggests that beta adrenergic receptor antagonists reduce opiate-induced
hyperalgesia (OIH). The purpose of this study is to determine the analgesic and
antihyperalgesic properties of the beta-blocker propranolol on remifentanil-induced
hypersensitivity in humans.
The investigators want to determine the analgesic and antihyperalgesic properties of the
beta-blocker propranolol on remifentanil-induced hypersensitivity in humans. The
investigators hope to learn whether the administration of beta-blocker propranolol will
significantly diminish the hyperalgesic response after administration of an opioid.
The primary outcome measure for this study is change in size (area) of secondary hyperalgesia
after cessation of remifentanil infusion, a measure of OIH.
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