Hypertension Clinical Trial
Official title:
Aldosterone-Renin Ratio to Diagnose Primary Aldosteronism in a Population of Patients With Therapy-Resistant Hypertension: Test Characteristics, Diagnostic Value and Predictive Value for Antihypertensive Treatment. The Dutch ARRAT Study.
This study aims to evaluate the diagnostic value of the Aldosterone-Renin Ratio (ARR)as a screening test for primary aldosteronism among hypertensives. The test characteristics will be studied. Furthermore, the effect of eplerenone, a selective aldosterone-receptor antagonist will be studied.
Although primary aldosteronism (PA) was formerly seen as a rare cause of hypertension, this
condition is now thought to be the commonest cause of secondary hypertension, with the
prevalence ranging up to 10-15 % of all hypertensives. Identification of patients with PA
allows for specific treatment, for instance unilateral adrenalectomy in case of an
aldosterone-producing adenoma or the administration of an aldosterone-receptor antagonist in
case of bilateral adrenal hyperplasia.
Since the introduction of the aldosterone-renin ratio (ARR) as a screening tool for PA in
1981, there has been considerable debate about the diagnostic value. The values for
aldosterone and renin are highly dependent on many factors, including posture, time of day
and medication. Also, the cut-off values for the identification of PA remain controversial.
This study aims to evaluate the test characteristics of the ARR in a population of patients
with therapy-resistant hypertension, the dependence of the ARR on medication type and the
predictive value on the response on eplerenone, a selective aldosterone-receptor antagonist.
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Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal
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