Relationship Between CETP Deficiency and Atherosclerosis in Patients With Hyperalphalipoproteinemia — INFINITY  

Hyper-LDL-cholesterolemia Clinical Trial

Official title: Investigation of Relationship Between Cholesteryl Ester Transfer Protein Deficiency and Carotid/Coronary Atherosclerosis in Patients With Hyperalphalipoproteinemia

Status Recruiting

Clinical Trial Summary

The aim of this study is to determine whether high high density lipoprotein-cholesterol(HDL-C) level and low Cholesteryl Ester Transfer Protein(CETP) activity is atherogenic or not in subjects who received health checkups. We investigate the association between CETP activities and the severity of atherosclerosis assessed by intima-media thickness (IMT) and compare the atherogenic change between in subjects with high HDL-C level, low HDL-C level, high CETP activities and low CETP activities by examining the morbidity rate of atherogenic diseases, the rate of ischemic electrocardiography(ECG) change, Calc Score of artery from chest X-ray, Ankle Brachial Index/Pulse Wave Velocity and various serum atherogenic markers. And we also examine the correlation between normal lipid profile and concentration, activity and function of surface lipoprotein in subjects with variety of lipoprotein levels, including patients with hyper-LDL-cholesterolemia, hyper-HDL-cholesterolemia with low or no CETP activity, patients with high level of remnant cholesterol or hyperlipoproteinemia of apolipoprotein(Apo)B-48.

Clinical Trial Description

n/a

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Atherosclerosis
• CETP Deficiency
• High Level of Remnant Cholesterol
• Hyper-LDL-cholesterolemia
• Hyperalphalipoproteinemia
• Hypercholesterolemia
• Lipid Metabolism, Inborn Errors
• Low CETP Activity

• NCT number: NCT01916512
• Study type: Observational
• Source: Osaka University
• Contact: Shizuya Yamashita, MD, PhD, FAHA, FJCC
• Phone: +81-6-6879-3633
• Email: shizu@cardiology.med.osaka-u.ac.jp
• Status: Recruiting
• Phase: N/A
• Start date: February 2012