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Long Term Immune Memory Responses to HPV Vaccination Following 2 vs 3 Doses of Quad-HPV Vaccine — Merck08  

Human Papillomavirus Clinical Trial

Official title:
Long Term Immune Memory Responses to Human Papillomavirus (HPV) Vaccination Following 2 Verses 3 Doses of Quadrivalent HPV Vaccine

Clinical Trial Summary

The overall aim of this study is to further understand the memory response to HPV vaccination in subjects who have received 2 versus 3 doses of quadrivalent HPV vaccine. Although memory responses can be detected shortly after immunization, the best approach to measure the long-lasting anamnestic response is to challenge with a booster dose years (> 5) after the original exposure.

Clinical Trial Description

This is a single center, interventional study to evaluate long term memory response to Q-HPV vaccination and to natural infection. Memory response will be assessed by measuring seroprotection 8-10 years post Q-HPV vaccination and to challenge with a booster dose years after the original exposure to measure the long-lasting anamnestic response. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02968420
Study type Interventional
Source University of British Columbia
Contact
Status Completed
Phase Phase 4
Start date September 11, 2017
Completion date May 15, 2019
View Details
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