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Human Papillomavirus (HPV) Oral Transmission Study in Partners Over Time — HOTSPOT  

Oropharyngeal Cancer Clinical Trial

Official title:
Human Papillomavirus (HPV) Oral Transmission Study in Partners Over Time

Clinical Trial Summary

This research is being done to understand more about a sexually transmitted virus called Human papillomavirus (HPV) in people with oropharyngeal cancer and their partners.

Clinical Trial Description

This study evaluates oral HPV infection and risk factors in people with head and neck cancer and their partners or spouses. The study focuses on oropharyngeal cancer patients and includes patients with HPV-associated and HPV-unassociated disease. A comparison group of people without cancer (controls) are also being enrolled. Couples are followed longitudinally and there is a repository of study samples. It is hoped that this research will help us understand risk factors for oral HPV infection, persistence and transmission as well as researching biomarkers for HPV-associated oral cancer and survival.

The study is led by Dr Amber D'Souza (Johns Hopkins) and laboratory testing for the study is performed in the laboratory of study co-investigator Dr Maura Gillison (Ohio University). The study biorepository is led by Dr karen Anderson (Arizona State). Participants are being enrolled at four sites across the United States including: Mt Sinai (site PI Dr Marshall Posner), Johns Hopkins (site PI Dr Sara Pai), Dana Farber Cancer Institute (site PI Dr Robert Haddad) and Oregon Health and Science University (site PI Dr Neil Gross). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01342978
Study type Observational
Source Johns Hopkins Bloomberg School of Public Health
Contact
Status Completed
Phase N/A
Start date October 2009
Completion date January 2017
View Details
See also
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