HIV Clinical Trial
Official title:
The Impact of Structured Exercise on Brain Health in HIV Positive Individuals
Exercise programs that combine resistance exercise with aerobic training yield optimal
health benefits for people with HIV. The global aim of this study is to contribute evidence
for the impact potential of a comprehensive exercise program on brain health in people with
HIV.
This study is part of a larger project based upon a cohort multiple randomized controlled
design. Within a fully characterized cohort which is followed over time, people meeting the
specific criteria for an exercise intervention will be identified. The sample will be
randomly selected to receive the intervention; the remaining eligible persons will serve as
controls. The intervention group will receive a 45 minute structured exercise program 3
times a week consisting of aerobic exercise and resistance training for a total of 12 weeks.
Exercise is an inexpensive intervention with widespread benefits to vascular and
musculoskeletal health and few harms. Showing an additional benefit to brain health and
cognition in particular is likely to encourage adoption and help elucidate mechanisms
underpinning brain health in HIV.
The primary objective of the study is to estimate, in comparison to individuals not offered
the exercise intervention, the extent to which a comprehensive exercise program impacts on
indicators of brain health, where these indicators are the primary outcome of cognitive
ability (B-CAM) and the related brain health outcomes of depression, anxiety, fatigue,
motivation, and speed of motor performance.
A secondary objective is to estimate the extent to which changes in brain health are
mediated through exercise induced changes in brain network function as measured by EEG
and/or by exercise induced changes in muscle power, aerobic capacity, physical function, and
body composition.
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