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Influence of Cytochrome P2B6 on Efavirenz Dose in HIV-infected Thai Patients

HIV Clinical Trial

Official title:
Influence of Cytochrome P2B6 on Efavirenz Dose in HIV-infected Thai Patients in a Prospective Randomized Controlled Trial: a Proof-of-concept Study

Clinical Trial Summary

Genetic polymorphisms of cytochrome P450 2B6 (CYP2B6) are associated with lower rate of EFV metabolism and lead to high exposure, as well as a higher risk of neuropsychiatric adverse event especially homozygous variant CYP2B6 *6/*6. This trial was designed to compare the proportion of patients who had undetectable HIV RNA at 24 weeks after ART initiation between patient who did CYP 2B6 guided EFV dose and who did not.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02421289
Study type Interventional
Source Mahidol University
Contact Pansachee Damronglerd, M.D.
Phone +66 8515-6188
Email joh_pum@yahoo.com
Status Unknown status
Phase Phase 1
Start date April 2013
View Details
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