HIV Clinical Trial
Official title:
Prevalence, Socio-demographic Correlates of Substance Use Disorders Among HIV-infected Adults in Cameroon, and Their Influence on Adherence to Antiretroviral Therapy and Immunological Feature: Study Protocol for a Retrospective Cohort Study
Background:
Data are scarce concerning injecting drug use (IDU) and alcohol consumption among
HIV-infected people on highly active antiretroviral treatment (HAART) in Cameroon. The aim
of this study is to determine the prevalence of alcohol consumption and IDU among
HIV-infected people on HAART; to determine sociodemographic factors associated with alcohol
abuse and IDU among people on HAART; and to determine impact of alcohol consumption and IDU
on adherence to HAART.
Methods/Design:
The investigators will conduct a cross sectional study at the Yaoundé Central Hospital in
Cameroon, from February to August 2015. Using a self-report questionnaire, the investigators
will include at least 1,000 HIV-infected adults (18 years or more) on HAART for at least one
month coming for HIV care. The investigators will exclude pregnant women. Data collection
will include sociodemographic and economic profile, alcohol consumption using Alcohol Use
Disorders Identification Test, injecting drug use, adherence to HAART using visual analog
scale and self-rate report. The investigators will perform sub-analysis for sex group and
area of habitation. A p value < 0.05 will be considered statistically significant.
Discussion:
There is a critical need of accurate estimates of the amplitude and the distribution of IDU
and alcohol consumption among HIV-infected adults, in order to inform health policies maker
for curbing burden of both injecting drug use and alcohol consumption among people living
with HIV.
Status | Not yet recruiting |
Enrollment | 1000 |
Est. completion date | December 2015 |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - aged 18 years or older - being for at least one month on highly active antiretroviral therapy Exclusion Criteria: - pregnant women |
Observational Model: Case-Only, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Goulfey Health District Unit | Edéa Regional Hospital, New York University School of Medicine, University of Yaounde 1, Yaounde Central Hospital |
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* Note: There are 22 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Alcohol consumption | The investigators will use the Alcohol Use Disorders Identification Test (AUDIT) to identify subjects with at-risk, hazardous, or harmful drinking. AUDIT has a possible range from 0 to 40. A score = 7 is classified as no current problem (low risk drinking), a score range between 8 - 15 is classified as probable current problem drinking (risky or hazardous drinking), a score range between 16 - 19 is classified as high risk or harmful drinking, and a score = 20 as define harm and likely to be alcohol dependent. The investigators prefer to use self-reported questionnaire vs. interview questionnaire because it may produce more accurate answers, but patients who will not well understand a question, could ask more clarifications. The investigators will therefore use AUDIT screening instrument test to classify current drinkers as problem or non-problem drinkers at cut-off = 8. | All days up to 180 days | No |
Other | Injecting drug use | Patients will report if Yes or No, they have already used an injectable drug. If yes, they will give frequency and last time of use. | All days up to 180 days | No |
Primary | Adherence to antiretroviral therapy | The investigators will measure adherence to antiretroviral therapy using a linear visual analogue scale on the past month as primary method of measure | All days up to 180 days | No |
Secondary | Self-rate of adherence to antiretroviral therapy | The investigators will measure adherence to antiretroviral therapy using self-rate by following scale: '1 - very good' to '5 - very bad' | All days up to 180 days | No |
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