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Longitudinal Evaluation of HIV-associated Lung Disease Phenotypes — LEAP  

HIV Clinical Trial

Official title:
The Study is a Multicenter, Prospective Observational Study of Pathogenesis of HIV Pulmonary Disease.

Clinical Trial Summary

The overall hypotheses of this proposal are that discrete phenotypes of HIV Chronic Obstructive Pulmonary disease (COPD) differ in their trajectories, biomarkers, and risk factors and that persistent viral infection including residual HIV is linked to HIV COPD.

Clinical Trial Description

The study is a multicenter, prospective observational study of pathogenesis of HIV pulmonary disease. We will determine the prevalence and risk factors for lung dysfunction as quantified by pulmonary function testing in HIV+ subjects. We will build on our existing longitudinal cohorts while adjusting for important co-variates such as antiretroviral therapy (ART), smoking history, co-infections, and illicit drug use. Evaluations will be scheduled at baseline, 18 months, and 36 months. (6, 12, 18 and 36 months for ART initiators at the UCSF). Study visits will consist of blood draw, questionnaires, pulmonary function testing, 6-minute walk test, CT of the chest at visit two. Oral specimen collection and glycocalyx and echocardiogram (visit two) at the Pittsburgh site only. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02238327
Study type Observational
Source University of Pittsburgh
Contact
Status Completed
Phase
Start date September 2014
Completion date March 2, 2020
View Details
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