Vitamin D Supplementation and CD4 Count in HIV-Infected Children

HIV Clinical Trial

Official title: Vitamin D Supplementation and CD4 Count in HIV-Infected Children

Status Completed

Clinical Trial Summary

To find out if vitamin D supplementing can lead to an improvement in immunological status in HIV-infected children as part of routine clinical care

Clinical Trial Description

The objective of this study is to determine the impact of vitamin D on immunological status in HIV-infected children as measured by CD4 count (CD4 percent). We will determine if vitamin D supplementation leads to a measurable change in CD4 count (CD4 percent) in HIV-infected children in the context of routine clinical care.

Specific study questions are:

1. Does vitamin D supplementation lead to a change in CD4 percent (CD4 count) in HIV-infected children?

2. Do the serum levels of the active form of vitamin D [1, 25(OH)2D and 25(OH)D] correlate with CD4 percent (CD4 count) in HIV-infected children? ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• HIV

• NCT number: NCT00911664
• Study type: Interventional
• Source: The Hospital for Sick Children
• Status: Completed
• Phase: Phase 2
• Start date: February 2009
• Completion date: July 2010