Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03001128
Other study ID # ACTG A5345
Secondary ID UM1AI068636
Status Completed
Phase
First received
Last updated
Start date February 23, 2017
Est. completion date January 29, 2021

Study information

Verified date March 2021
Source AIDS Clinical Trials Group
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study is to collect information about what happens when people pause, or temporarily stop taking, ART, and to collect blood samples from these people at frequent intervals. We will also study the safety of pausing ART under close observation.


Recruitment information / eligibility

Status Completed
Enrollment 61
Est. completion date January 29, 2021
Est. primary completion date January 29, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years to 70 Years
Eligibility Step 1 Inclusion Criteria: - HIV-1 infection, documented by any licensed rapid HIV test or HIV enzyme or chemiluminescence immunoassay (E/CIA) test kit at any time prior to study entry and confirmed by a licensed Western blot or a second antibody test by a method other than the initial rapid HIV and/or E/CIA, or by HIV-1 antigen, plasma HIV-1 RNA viral load. NOTE: The term "licensed" refers to a US FDA-approved kit, which is required for all IND studies, or for sites located in countries other than the United States, a kit that has been certified or licensed by an oversight body within that country and validated internally. - Plasma HIV-1 RNA >1000 copies/mL by any assay obtained prior to initiating ART. NOTE: Documentation or candidate recall is acceptable. - For Cohort A participants, ART initiated during chronic infection (e.g., more than 6 months after estimated date of infection, or as determined by site investigator, study team, or available medical records). - For Cohort B, diagnosis of acute HIV infection (AHI) as defined by the criteria listed below. Fiebig Staging Criteria (must be source documented): - Fiebig I-II: E/CIA negative, HIV-1 RNA or p24 antigen positive, and negative or indeterminate Western blot, if performed - Fiebig III-IV: Reactive HIV-1 antibody and negative or indeterminate results on the Western blot or Geenius HIV-1/HIV-2 - Fiebig V: Reactive HIV-1 antibody and positive Western blot or Geenius HIV-1/HIV-2 without p31 band NOTE A: ART must have been initiated more than 10 days after Fiebig I-II diagnosis and less than 90 days after Fiebig V diagnosis to qualify for Cohort B. NOTE B: Candidates who were diagnosed with Fiebig I-II AHI must have had a positive HIV-1 RNA test or subsequently have had a positive Western blot if no positive HIV-1 RNA test was available. - Receiving continuous ART for at least 2 years and on any NNRTI-, PI-, or INSTI-containing regimen. NOTE A: ART interruptions of up to 7 days and at least 90 days prior to entry are acceptable. NOTE B: Within- and between-class changes in ART within the previous 2 years are acceptable. - For candidates whose ART includes an NNRTI, willingness and ability to change to a PI- or INSTI-containing regimen for at least 4 weeks prior to ART interruption and the local availability of such a regimen. - Nadir CD4+ cell count =200 cells/mm3. NOTE: Candidate recall or documentation is acceptable. - CD4+ cell count =500 cells/mm3 obtained within 90 days prior to study entry in a US laboratory that has is compliant with Clinical Laboratory Improvement Amendments (CLIA) or its equivalent or in any network approved non-US laboratory that operates in accordance with Good Clinical Laboratory Practices (GCLP) and participates in appropriate external quality assurance (EQA) programs. - One documented plasma HIV-1 RNA that is below the limit of detection of an FDA-approved assays (limit of detection: 75, 50, 40, or 20 copies/mL) between 12 and 24 months prior to the screening HIV-1 RNA and one documented HIV-1 RNA that is below the limit of detection of the FDA-approved assays (limit of detection: 75, 50, 40, or 20 copies/mL) collected fewer than 12 months prior to the screening HIV-1 RNA. - Plasma HIV-1 RNA level below the limit of assay quantification within 90 days prior to entry. - The following laboratory values obtained within 90 days prior to entry by any US laboratory that is compliant with CLIA or its equivalent or in any network approved non-US laboratory that operates in accordance with GCLP and participates in appropriate EQA programs. Absolute neutrophil count (ANC) =750 cells/mm3 Hemoglobin =11.0 g/dL for men and =10.0 g/dL for women Platelet count =100,000/mm3 Creatinine =1.5 mg/dL Aspartate aminotransferase (AST) (SGOT) =1.5x upper limit of normal (ULN) Alanine aminotransferase (ALT) (SGPT) =1.5x ULN - HCV antibody negative result obtained within 90 days prior to study entry or, if the HCV antibody result is positive, a negative HCV RNA result within 90 days prior to study entry and no positive HCV RNA result within 24 weeks prior to entry. - Ability and willingness of participant to provide informed consent. - Willingness to have blood samples collected and stored indefinitely and used for HIV-related research purposes. - For females of reproductive potential (women who have not been post-menopausal for at least 24 consecutive months, i.e., who have had menses within the preceding 24 months, or women who have not undergone surgical sterilization, specifically hysterectomy, or bilateral oophorectomy and/or bilateral salpingectomy), a negative serum or urine pregnancy test within 48 hours prior to study entry by any clinic or laboratory that has a CLIA certification or its equivalent, or is using a point of care CLIA-waived test, or at any network approved non-US laboratory or clinic that operates in accordance with Good Clinical Laboratory Practices and participates in appropriate external quality assurance programs. NOTE: Acceptable documentation of hysterectomy and bilateral oophorectomy, bilateral salpingectomy, tubal micro-inserts, partner who has undergone vasectomy, and menopause is participant-reported history. - All participants must agree to use barrier protection (e.g., condoms, dental dams) for all sexual activity throughout the entire course of the study to prevent HIV transmission. - All participants must agree not to participate in the conception process (e.g., active attempt to become pregnant or to impregnate, sperm donation, or in vitro fertilization). If participating in sexual activity that could lead to pregnancy, the participant/partner must use at least two reliable forms of contraceptives (e.g., condoms, with or without a spermicidal agent; a diaphragm or cervical cap with spermicide; an IUD; hormone-based contraception), with at least one being a barrier method, during the study. - Site investigator anticipates that a fully active alternative ART regimen could be constructed and would be available in the event of virologic failure on the participant's current ART regimen. - Absence of either active hepatitis B virus (HBV) infection, indicated by a negative hepatitis B surface antigen (HBsAg) or HBV viral load assays within 90 days prior to entry or known chronic hepatitis B infection based on a previously positive HBV DNA or positive HBsAg without a subsequent positive hepatitis B surface antibody (HBsAb). Step 1 Exclusion Criteria: - Any plasma HIV-1 RNA at or above the limit of detection of the FDA-approved assays (limit of detection: 75, 50, 40, or 20 copies/mL) within 24 months prior to entry. NOTE: A single unconfirmed "blip" (i.e., plasma HIV-1 RNA over limit of detection but <200 copies/mL) is allowed if preceded and followed by values below the limit of detection and if the blip occurred more than 6 months prior to study entry. - Currently breastfeeding or plans on breastfeeding during the course of the study or is pregnant. - Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements. - Acute or serious illness, in the opinion of the site investigator, requiring systemic treatment and/or hospitalization within 60 days prior to entry. - Any history of an AIDS-defining illness using the current list on the U.S. Centers for Disease Control and Prevention (CDC)'s website. - Receipt of any study-defined prohibited medications within 6 months prior to entry. - Prior history of difficulty establishing venous access or current contraindication for leukapheresis, in the opinion of the site investigator and based on assessments. - Receipt of any vaccination within 1 week prior to entry. NOTE: The entry visit must be scheduled to ensure that 1 week has elapsed after any vaccination.

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Antiretroviral treatment pause
Antiretroviral treatment pause

Locations

Country Name City State
Puerto Rico 5401 Puerto Rico AIDS Clinical Trials Unit CRS San Juan
Thailand 31802 Thai Red Cross AIDS Research Centre (TRC-ARC) CRS Bangkok Patumwan
United States University of Colorado Hospital CRS (6101) Aurora Colorado
United States 101 Massachusetts General Hospital (MGH) CRS Boston Massachusetts
United States 107 Brigham and Women's Hosp. ACTG CRS Boston Massachusetts
United States 3201 Chapel Hill CRS Chapel Hill North Carolina
United States 2701 Northwestern University CRS Chicago Illinois
United States Rush Univ. Med. Ctr. ACTG CRS (2702) Chicago Illinois
United States 31443 Trinity Health and Wellness Center CRS Dallas Texas
United States 3203 Greensboro CRS Greensboro North Carolina
United States 601 University of California, Los Angeles CARE Center CRS Los Angeles California
United States 3652 Vanderbilt Therapeutics (VT) CRS Nashville Tennessee
United States Pittsburgh CRS (1001) Pittsburgh Pennsylvania
United States University of Rochester Adult HIV Therapeutic Strategies Network CRS (31787) Rochester New York
United States Washington U CRS (2101) Saint Louis Missouri
United States 701 University of California, San Diego AntiViral Research Center CRS San Diego California
United States 801 University of California, San Francisco HIV/AIDS CRS San Francisco California
United States Whitman Walker Health CRS (31791) Washington District of Columbia

Sponsors (2)

Lead Sponsor Collaborator
AIDS Clinical Trials Group National Institute of Allergy and Infectious Diseases (NIAID)

Countries where clinical trial is conducted

United States,  Puerto Rico,  Thailand, 

Outcome

Type Measure Description Time frame Safety issue
Primary Time from ART discontinuation to HIV RNA rebound Time from ART discontinuation (start of MAP) to HIV RNA rebound to = 1,000 copies/mL Up to 96 weeks following ART discontinuation
Primary Frequency of sustained post-treatment HIV control Frequency of sustained post-treatment HIV control in participants treated during early and chronic infection undergoing an IMAP =24 weeks off ART without meeting ART re-initiation criteria
Primary Association between pre-IMAP CA-RNA and time to HIV rebound Association between pre-IMAP CA-RNA and time to HIV rebound Up to 96 weeks following ART discontinuation
See also
  Status Clinical Trial Phase
Completed NCT03188523 - Activity of MK-8504 in Anti-retroviral-naïve, Human Immunodeficiency Virus 1 (HIV-1) Infected Participants (MK-8504-002) Phase 1
Recruiting NCT06185452 - Implementation of Out-of-HOspital Administration of the Long-Acting Cabotegravir+Rilpivirine Phase 4
Recruiting NCT02881320 - Study of Bictegravir/Emtricitabine/Tenofovir Alafenamide Fixed Dose Combination in Adolescents and Children With Human Immunodeficiency Virus-1 Phase 2/Phase 3
Completed NCT02513771 - Sitagliptin for Reducing Inflammation and Immune Activation Phase 2
Completed NCT02542852 - A Study of a Nucleoside Sparing Regimen in HIV-1 Infected Patients With Detectable Viremia Phase 2
Completed NCT02057796 - Systematic Empirical vs. Test-guided Anti-TB Treatment Impact in Severely Immunosuppressed HIV-infected Adults Initiating ART With CD4 Cell Counts <100/mm3 Phase 4
Terminated NCT02732457 - Allogeneic Hematopoietic Stem Cell Transplantation in HIV-1 Infected Patients
Completed NCT01989910 - Compare the Efficacy and Safety of Raltegravir Versus Efavirenz Combination Therapy in Treatment-naïve HIV-1 Patients Phase 4
Completed NCT01627678 - Immunotherapy With Vacc-C5 With Adjuvant GM-CSF or Alhydrogel in HIV-1-infected Subjects on ART Phase 1/Phase 2
Completed NCT01704781 - Vacc-4x + Lenalidomide vs. Vacc-4x +Placebo in HIV-1-infected Subjects on Antiretroviral Therapy (ART) Phase 1/Phase 2
Completed NCT01403051 - High Dose Vitamin D and Calcium for Bone Health in Individuals Initiating HAART Phase 2
Completed NCT01466595 - Rifaximin as a Modulator of Microbial Translocation and Immune Activation Phase 2
Completed NCT01348308 - Immuno-stimulation With Maraviroc Combined to Antiretroviral Therapy in Advanced Late Diagnosed HIV-1 Infected Patients Phase 3
Completed NCT01511809 - Efficacy of Atazanavir/Ritonavir Monotherapy as Maintenance in Patients With Viral Suppression Phase 3
Completed NCT01019551 - Therapeutic Intensification Plus Immunomodulation in HIV-infected Patients Phase 2
Terminated NCT01130376 - Novel Interventions in HIV-1 Infection Phase 1
Completed NCT00323687 - SONETT: Switch Study to Once Daily HIV Treatment Regimen With Truvada Phase 4
Completed NCT04003103 - Safety and Pharmacokinetics of Oral Islatravir (MK-8591) Once Monthly in Participants at Low Risk of Human Immunodeficiency Virus 1 (HIV-1) Infection (MK-8591-016) Phase 2
Completed NCT02527096 - A Trial Evaluating Maintenance Therapy With Lamivudine (Epivir®) and Dolutegravir (Tivicay®) in Human Immunodeficiency Virus 1 (HIV-1) Infected Patients Virologically Suppressed With Triple Highly Active Antiretroviral Therapy (HAART) (ANRS 167 Lamidol) Phase 2
Active, not recruiting NCT04776252 - Open-label, Follow-up of Doravirine/Islatravir (DOR/ISL 100 mg/0.75mg) for Participants With Human Immunodeficiency Virus-1 (HIV-1) Infection (MK-8591A-033) Phase 3