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Individualization Flow in Patients Treated With High Flow Nasal Therapy (iFLOW) — iFLOW  

Respiratory Failure Clinical Trial

Official title:
Assessing Recruitability for Flow Individualization in Patients Treated With Nasal High Flow: a Physiological Study (The iFLOW Study)

Clinical Trial Summary

In patients with acute hypoxemic respiratory failure (AHRF), High Flow Nasal Therapy (HFNT) improves oxygenation, tolerance, and decreases work of breathing as compared to standard oxygen therapy by facemask. The hypothesis is that this flow challenge (ROX index variation from 30 to 60L/min) could be used as a test for assessing changes in lung aeration, analyzed by the variation in end expiratory lung volume (ΔEELV), in patients treated with HFNC. It may allow to personalize the flow settings during HFNC. In this sense, an increase in EELV will be observed with higher flows in responders and, therefore, these participants may benefit from increasing the flow. In contrast, to increase the flow in non-responders (no significant increase in EELV with higher flows) increase the risk of patient self-inflicted lung injury (P-SILI).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05401474
Study type Interventional
Source Hospital Universitari Vall d'Hebron Research Institute
Contact Oriol Roca, MD PhD
Phone +34932746209
Email oroca@vhebron.net
Status Recruiting
Phase N/A
Start date March 18, 2022
Completion date February 28, 2023
View Details
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