High Blood Pressure Clinical Trial
Official title:
Effect of Vitamin D Supplementation on Blood Pressure in Elderly People
Verified date | November 2017 |
Source | Universidad de Colima |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The prevalence and incidence of cardiovascular disease (such as Hypertension) increases exponentially with age (McDermott, 2007;) These diseases account for 30% of the global mortality (WHO, 2011). Vitamin D (VD) insufficiency affects as many as half of otherwise healthy adults in developed countries (Holick, 2007). VD is implicated in the control of blood pressure (BP) through inhibition of the renin-angiotensin system (Yamshchikov, 2009), although the role of VD supplementation for prevention and treatment of the HTA is controversial.The purpose of this study was to investigate if VD supplement in elderly people reduces the levels of BP.
Status | Completed |
Enrollment | 45 |
Est. completion date | June 2013 |
Est. primary completion date | April 2013 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 60 Years and older |
Eligibility |
Inclusion Criteria: - Adults aged = 60 years with essential hypertension. - Subjects on anti-hypertensive for more than 10 years and the dosages were unchanged during the study. Exclusion Criteria: - Subjects who had been treated with vitamin D within the last three months. - None were on hormone replacement therapy. |
Country | Name | City | State |
---|---|---|---|
Mexico | Facultad de Medicina-Universidad de Colima | Colima |
Lead Sponsor | Collaborator |
---|---|
Universidad de Colima |
Mexico,
Holick MF, Smith E, Pincus S. Skin as the site of vitamin D synthesis and target tissue for 1,25-dihydroxyvitamin D3. Use of calcitriol (1,25-dihydroxyvitamin D3) for treatment of psoriasis. Arch Dermatol. 1987 Dec;123(12):1677-1683a. Review. — View Citation
McDermott MM. The international pandemic of chronic cardiovascular disease. JAMA. 2007 Mar 21;297(11):1253-5. — View Citation
WHO, World Heart Federation, World Stroke Organization. Global atlas on cardiovascular disease prevention and control. The Atlas of Heart Disease and Stroke. World Health Organization, 2011;8-13
Yamshchikov AV, Desai NS, Blumberg HM, Ziegler TR, Tangpricha V. Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials. Endocr Pract. 2009 Jul-Aug;15(5):438-49. doi: 10.4158/EP09101.ORR. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Difference of systolic and diastolic blood pressure | Difference between systolic and diastolic blood pressure before and after treatment. | 6 weeks | |
Secondary | Difference of Serum 25-Hidroxyvitamin-D | Difference between 25-Hidroxyvitamin-D before and after treatment. | 6 weeks |
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