Heart and Blood Pressure Study: The Effect of Aortic Impedance on Myocardial Relaxation

High Blood Pressure Clinical Trial

Official title:

The Effect of Aortic Impedance on Myocardial Relaxation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00204984
• Other study ID #: H-2004-0382
• Secondary ID: K23 AGO01022
• Status: Completed
• Phase: N/A
• Start date: May 2005
• Est. completion date: December 20, 2006

Study information

• Verified date: February 2019
• Source: University of Wisconsin, Madison
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Does dilation of blood vessels (vasodilation), which decreases aortic stiffness, have a greater effect on heart myocardium relaxation (diastole) than vasodilation which affects mean pressure equally without improving aortic stiffness?

Description:

60 subjects, 30 with hypertension and 30 without will attend two visits to the GCRC. At each visit, pulsatile hemodynamics (by using tonometry—a non-invasive means to obtain arterial pressure tracings) and Doppler tissue imaging relaxation velocity (a measurement of myocardial relaxation obtained by echocardiography) data will be collected before and after administration of vasodilator medication. At the first visit, each patient will receive an oral dose of the vasodilator hydralazine (does not effect aortic stiffness), and at the second visit each patient will receive intravenous nesiritide (does effect aortic stiffness). The relationship between timing of the reflected pulse wave and myocardial relaxation velocity will be studied at baseline and following administration of each vasodilator to determine if changing aortic stiffness has an impact on myocardial relaxation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: December 20, 2006
• Est. primary completion date: December 20, 2006
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• Subjects over the age of 65

Exclusion Criteria:

• Have known or suspected coronary artery disease

• Have known or suspected left ventricular dysfunction

• Have significant valvular, infiltrative, pericardial, or congenital heart disease

• Have a resting systolic blood pressure < 100 mmHg

• Have had an adverse reaction to nesiritide or hydralazine

• Have a serum creatinine > 2 mg/dl at Visit 1

Related Conditions & MeSH terms

• High Blood Pressure
• Hypertension

Intervention

Drug:
• oral hydralazine and intravenous nesiritide
vasodilators

Locations

Country	Name	City	State
United States	University of Wisconsin Hospital & Clinics	Madison	Wisconsin

Sponsors (2)

Lead Sponsor	Collaborator
University of Wisconsin, Madison	Scios, Inc.

Country where clinical trial is conducted

United States, 

References & Publications (1)

Sweitzer NK, Hetzel SJ, Skalski J, Velez M, Eggleston K, Mitchell GF. Left ventricular responses to acute changes in late systolic pressure augmentation in older adults. Am J Hypertens. 2013 Jul;26(7):866-71. doi: 10.1093/ajh/hpt043. Epub 2013 Mar 28. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	heart myocardium relaxation (diastole)		before and after administration of vasodilator medication