High Blood Pressure Clinical Trial
Official title:
The Effect of Aortic Impedance on Myocardial Relaxation
Does dilation of blood vessels (vasodilation), which decreases aortic stiffness, have a greater effect on heart myocardium relaxation (diastole) than vasodilation which affects mean pressure equally without improving aortic stiffness?
60 subjects, 30 with hypertension and 30 without will attend two visits to the GCRC. At each visit, pulsatile hemodynamics (by using tonometry—a non-invasive means to obtain arterial pressure tracings) and Doppler tissue imaging relaxation velocity (a measurement of myocardial relaxation obtained by echocardiography) data will be collected before and after administration of vasodilator medication. At the first visit, each patient will receive an oral dose of the vasodilator hydralazine (does not effect aortic stiffness), and at the second visit each patient will receive intravenous nesiritide (does effect aortic stiffness). The relationship between timing of the reflected pulse wave and myocardial relaxation velocity will be studied at baseline and following administration of each vasodilator to determine if changing aortic stiffness has an impact on myocardial relaxation. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03812614 -
Comparative Effectiveness of Family vs. Individually Focused Diabetes Education and Support
|
N/A | |
Completed |
NCT03650166 -
High BP and Home Monitoring Experience (HoME) Study
|
N/A | |
Recruiting |
NCT02908139 -
Noninvasive Perioperative Monitoring of Arterial Stiffness, Volume and Nutritional Status in Stable Renal Transplant Recipients
|
N/A | |
Completed |
NCT01622400 -
Efficacy of a Dedicated Therapeutic Education Program in Patients at High Cardiovascular Risk
|
N/A | |
Completed |
NCT00659672 -
Effect of Whey Protein on Blood Pressure
|
N/A | |
Completed |
NCT00473681 -
Intervention Study to Control High Blood Pressure for Korean American
|
N/A | |
Completed |
NCT03542240 -
Effects of Curcumin Supplementation on Gut Barrier Function in Patients With Metabolic Syndrome
|
N/A | |
Active, not recruiting |
NCT05526092 -
OAT-GUT-BRAIN: Effects of Oats and Rice on Comprehensive Health of Metabolically Challenged Individuals
|
N/A | |
Completed |
NCT02218931 -
ESTEEM - Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes
|
N/A | |
Recruiting |
NCT03753204 -
Salt-Sensitivity and Immunity Cell Activation
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT04064281 -
The Healthy Cantonese Diet on Cardiometabolic Syndrome
|
N/A | |
Completed |
NCT04479384 -
The Immediate Effect of an Osteopathic Manual Treatment on Blood Pressure in Adults With Hypertension - a Pilot Study.
|
N/A | |
Completed |
NCT04082819 -
MediBeat - HeartBeat Observation Trial
|
N/A | |
Completed |
NCT03555344 -
Effect of Mantra on Hypertensive Patients
|
N/A | |
Withdrawn |
NCT03319823 -
Treating Nocturnal Hypertension and Nocturia in African American Men
|
Phase 4 | |
Completed |
NCT00689819 -
Pre-clinical Cardiac Dysfunction Among Asymptomatic Hypertensive Patients
|
N/A | |
Completed |
NCT00417170 -
Comparison of Aliskiren and Amlodipine on Insulin Resistance and Endothelial Dysfunction in Patients With Hypertension and Metabolic Syndrome
|
Phase 2 | |
Completed |
NCT00130156 -
Effects of Combination Therapy With Alpha-1 Blocker (Bunazosin or Doxazosin) in the Treatment of Patients With Mild to Moderate Essential Hypertension
|
Phase 4 | |
Completed |
NCT05808556 -
Sticker Pad Containing Essential Oil in Volunteer With High Blood Pressure
|
N/A | |
Recruiting |
NCT05321368 -
A Cardiometabolic Health Program Linked With Clinical-Community Support and Mobile Health Telemonitoring to Reduce Health Disparities
|
N/A |