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Effects of Combination Therapy With Alpha-1 Blocker (Bunazosin or Doxazosin) in the Treatment of Patients With Mild to Moderate Essential Hypertension

High Blood Pressure Clinical Trial

Official title:
Effects of Combination Therapy With an α1-blocker (Sustained-release Preparation of Bunazosin or Doxazosin) in Inadequate Responders to an Angiotensin II Antagonist (Valsartan) in the Treatment of Patients With Mild to Moderate Essential Hypertension

Clinical Trial Summary

The purpose of this study is to investigate the efficacy and safety of Bunazosin with Valsartin compared to Doxazosin with Valsartin for patients with mild to moderate essential hypertension accompanied by metabolic syndrome.

Clinical Trial Description

This clinical study will comprise a 1 to 2-week washout period, a 5-week mono therapy period with Angiotensinâ…ˇantagonist, and an 8-week alpha blocker add-on treatment period. Total study period will be 15 weeks. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00130156
Study type Interventional
Source Eisai Inc.
Contact
Status Completed
Phase Phase 4
Start date October 2005
Completion date March 2009
View Details
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